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Research Article

Structural Analysis of Specific Metal Chelating Inhibitor Binding to the Endonuclease Domain of Influenza pH1N1 (2009) Polymerase

  • Eva Kowalinski,

    Affiliations: European Molecular Biology Laboratory, Grenoble Outstation, BP181, Grenoble, France, Unit of Virus Host-Cell Interactions, UJF-EMBL-CNRS, UMI 3265, BP181, Grenoble, France

    a Current address: Max-Planck Institute for Biochemistry, Martinsried, Germany

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  • Chloe Zubieta,

    Affiliations: European Molecular Biology Laboratory, Grenoble Outstation, BP181, Grenoble, France, Unit of Virus Host-Cell Interactions, UJF-EMBL-CNRS, UMI 3265, BP181, Grenoble, France

    b Current address: European Synchrotron Radiation Facility, BP 220, Grenoble, France

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  • Andrea Wolkerstorfer,

    Affiliation: Savira pharmaceuticals Gmbh, Vienna, Austria

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  • Oliver H. J. Szolar,

    Affiliation: Savira pharmaceuticals Gmbh, Vienna, Austria

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  • Rob W. H. Ruigrok,

    Affiliation: Unit of Virus Host-Cell Interactions, UJF-EMBL-CNRS, UMI 3265, BP181, Grenoble, France

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  • Stephen Cusack mail

    cusack@embl.fr

    Affiliations: European Molecular Biology Laboratory, Grenoble Outstation, BP181, Grenoble, France, Unit of Virus Host-Cell Interactions, UJF-EMBL-CNRS, UMI 3265, BP181, Grenoble, France

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  • Published: August 02, 2012
  • DOI: 10.1371/journal.ppat.1002831

About the Authors

Eva Kowalinski, Chloe Zubieta, Stephen Cusack
European Molecular Biology Laboratory, Grenoble Outstation, BP181, Grenoble, France
Eva Kowalinski, Chloe Zubieta, Rob W. H. Ruigrok, Stephen Cusack
Unit of Virus Host-Cell Interactions, UJF-EMBL-CNRS, UMI 3265, BP181, Grenoble, France
Andrea Wolkerstorfer, Oliver H. J. Szolar
Savira pharmaceuticals Gmbh, Vienna, Austria

Corresponding Author

Email: cusack@embl.fr

Competing Interests

Andrea Wolkerstofer and Oliver Szolar are employed by Savira pharmaceuticals (http://www.savira.at/). Stephen Cusack was involved in the foundation of Savira and is scientific advisor to the company.

Author Contributions

Conceived and designed the experiments: EK CZ AW OHJS RWHR SC. Performed the experiments: EK CZ AW SC. Analyzed the data: EK CZ AW SC. Contributed reagents/materials/analysis tools: EK CZ AW. Wrote the paper: EK AW SC.