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Research Article

The Molecular Basis of Drug Resistance against Hepatitis C Virus NS3/4A Protease Inhibitors

  • Keith P. Romano,

    Affiliation: Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America

    X
  • Akbar Ali,

    Affiliation: Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America

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  • Cihan Aydin,

    Affiliation: Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America

    X
  • Djade Soumana,

    Affiliation: Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America

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  • Ayşegül Özen,

    Affiliation: Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America

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  • Laura M. Deveau,

    Affiliation: Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America

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  • Casey Silver,

    Affiliation: Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America

    X
  • Hong Cao,

    Affiliation: Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America

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  • Alicia Newton,

    Affiliation: Monogram Biosciences, San Francisco, California, United States of America

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  • Christos J. Petropoulos,

    Affiliation: Monogram Biosciences, San Francisco, California, United States of America

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  • Wei Huang,

    Affiliation: Monogram Biosciences, San Francisco, California, United States of America

    X
  • Celia A. Schiffer mail

    Celia.Schiffer@umassmed.edu

    Affiliation: Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America

    X
  • Published: July 26, 2012
  • DOI: 10.1371/journal.ppat.1002832

About the Authors

Keith P. Romano, Akbar Ali, Cihan Aydin, Djade Soumana, Ayşegül Özen, Laura M. Deveau, Casey Silver, Hong Cao, Celia A. Schiffer
Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America
Alicia Newton, Christos J. Petropoulos, Wei Huang
Monogram Biosciences, San Francisco, California, United States of America

Corresponding Author

Email: Celia.Schiffer@umassmed.edu

Competing Interests

Alicia Newton, Christos J. Petropoulos, and Wei Huang are employees of Monogram Biosciences. From roughly 2008 - August 2010 Celia Schiffer served as a consultant to Monogram Biosciences, on topics unrelated to this research and thus has no competing interest. Since the completion of this research project Celia Schiffer has received small "Sponsored Research Grants" from Avila (CelGene) and Merck. This does not alter our adherence to all PLoS Pathogens policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: CAS KPR AA. Performed the experiments: KPR AA CA DS AO LMD CS HC AN WH. Analyzed the data: KPR AA CAS. Contributed reagents/materials/analysis tools: KPR AA CA DS AO LMD CS HC AN CJP WH. Wrote the paper: KPR AA CAS.