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Research Article

Human Papillomavirus Type 8 Interferes with a Novel C/EBPβ-Mediated Mechanism of Keratinocyte CCL20 Chemokine Expression and Langerhans Cell Migration

  • Tanya Sperling equal contributor,

    equal contributor Contributed equally to this work with: Tanya Sperling, Monika Ołdak

    Affiliation: Institute of Virology and Center for Molecular Medicine Cologne, University of Cologne, Cologne, Germany

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  • Monika Ołdak equal contributor,

    equal contributor Contributed equally to this work with: Tanya Sperling, Monika Ołdak

    Affiliations: Institute of Virology, Saarland University, Homburg/Saar, Germany, Department of Histology and Embryology Center of Biostructure Research, Medical University of Warsaw, Warsaw, Poland

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  • Barbara Walch-Rückheim,

    Affiliation: Institute of Virology, Saarland University, Homburg/Saar, Germany

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  • Claudia Wickenhauser,

    Affiliations: Institute of Pathology, University of Cologne, Cologne, Germany, Institute of Pathology, University of Leipzig, Leipzig, Germany

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  • John Doorbar,

    Affiliation: Division of Virology, National Institute for Medical Research, Mill Hill, London, United Kingdom

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  • Herbert Pfister,

    Affiliation: Institute of Virology and Center for Molecular Medicine Cologne, University of Cologne, Cologne, Germany

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  • Magdalena Malejczyk,

    Affiliation: Department of Dermatology and Venereology, Medical University of Warsaw, Warsaw, Poland

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  • Sławomir Majewski,

    Affiliation: Department of Dermatology and Venereology, Medical University of Warsaw, Warsaw, Poland

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  • Andrew C. Keates,

    Affiliation: Division of Gastroenterology, Beth Israel Deaconess Medical Center, Boston, Massachusetts, United States of America

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  • Sigrun Smola mail

    sigrun.smola@uks.eu

    Affiliations: Institute of Virology and Center for Molecular Medicine Cologne, University of Cologne, Cologne, Germany, Institute of Virology, Saarland University, Homburg/Saar, Germany

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  • Published: July 26, 2012
  • DOI: 10.1371/journal.ppat.1002833

About the Authors

Tanya Sperling, Herbert Pfister, Sigrun Smola
Institute of Virology and Center for Molecular Medicine Cologne, University of Cologne, Cologne, Germany
Monika Ołdak, Barbara Walch-Rückheim, Sigrun Smola
Institute of Virology, Saarland University, Homburg/Saar, Germany
Monika Ołdak
Department of Histology and Embryology Center of Biostructure Research, Medical University of Warsaw, Warsaw, Poland
Claudia Wickenhauser
Institute of Pathology, University of Cologne, Cologne, Germany
Claudia Wickenhauser
Institute of Pathology, University of Leipzig, Leipzig, Germany
John Doorbar
Division of Virology, National Institute for Medical Research, Mill Hill, London, United Kingdom
Magdalena Malejczyk, Sławomir Majewski
Department of Dermatology and Venereology, Medical University of Warsaw, Warsaw, Poland
Andrew C. Keates
Division of Gastroenterology, Beth Israel Deaconess Medical Center, Boston, Massachusetts, United States of America

Corresponding Author

Email: sigrun.smola@uks.eu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: SS TS MO BW. Performed the experiments: TS MO BW CW JD. Analyzed the data: TS SS MO BW JD. Contributed reagents/materials/analysis tools: MM SM ACK HP JD. Wrote the paper: SS MO TS.