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Research Article

AsrR Is an Oxidative Stress Sensing Regulator Modulating Enterococcus faecium Opportunistic Traits, Antimicrobial Resistance, and Pathogenicity

  • François Lebreton,

    Affiliation: University of Caen Basse-Normandie, EA4655 (team “Antibioresistance”), Medical School, Caen, France

    Current address: Massachusetts Eye and Ear Infirmary, Department of Microbiology and Immunobiology, Harvard Medical School, Boston, Massachusetts, United States of America

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  • Willem van Schaik,

    Affiliation: University Medical Center Utrecht, Department of Medical Microbiology, Utrecht, The Netherlands

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  • Maurizio Sanguinetti,

    Affiliation: Catholic University of Sacred Heart, Institute of Microbiology, Rome, Italy

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  • Brunella Posteraro,

    Affiliation: Catholic University of Sacred Heart, Institute of Hygiene, Rome, Italy

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  • Riccardo Torelli,

    Affiliation: Catholic University of Sacred Heart, Institute of Microbiology, Rome, Italy

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  • Florian Le Bras,

    Affiliation: University of Caen Basse-Normandie, EA4655 (team “Antibioresistance”), Medical School, Caen, France

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  • Nicolas Verneuil,

    Affiliation: University of Caen Basse-Normandie, EA4655 (team “Stress and Virulence”), Caen, France

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  • Xinglin Zhang,

    Affiliation: University Medical Center Utrecht, Department of Medical Microbiology, Utrecht, The Netherlands

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  • Jean-Christophe Giard,

    Affiliation: University of Caen Basse-Normandie, EA4655 (team “Antibioresistance”), Medical School, Caen, France

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  • Anne Dhalluin,

    Affiliation: University of Caen Basse-Normandie, EA4655 (team “Antibioresistance”), Medical School, Caen, France

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  • Rob J. L. Willems,

    Affiliation: University Medical Center Utrecht, Department of Medical Microbiology, Utrecht, The Netherlands

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  • Roland Leclercq,

    Affiliations: University of Caen Basse-Normandie, EA4655 (team “Antibioresistance”), Medical School, Caen, France, University Hospital of Caen, Department of Microbiology, Caen, France

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  • Vincent Cattoir mail

    cattoir-v@chu-caen.fr

    Affiliations: University of Caen Basse-Normandie, EA4655 (team “Antibioresistance”), Medical School, Caen, France, University Hospital of Caen, Department of Microbiology, Caen, France

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  • Published: August 02, 2012
  • DOI: 10.1371/journal.ppat.1002834

About the Authors

François Lebreton, Florian Le Bras, Jean-Christophe Giard, Anne Dhalluin, Roland Leclercq, Vincent Cattoir
University of Caen Basse-Normandie, EA4655 (team “Antibioresistance”), Medical School, Caen, France
Willem van Schaik, Xinglin Zhang, Rob J. L. Willems
University Medical Center Utrecht, Department of Medical Microbiology, Utrecht, The Netherlands
Maurizio Sanguinetti, Riccardo Torelli
Catholic University of Sacred Heart, Institute of Microbiology, Rome, Italy
Brunella Posteraro
Catholic University of Sacred Heart, Institute of Hygiene, Rome, Italy
Nicolas Verneuil
University of Caen Basse-Normandie, EA4655 (team “Stress and Virulence”), Caen, France
Roland Leclercq, Vincent Cattoir
University Hospital of Caen, Department of Microbiology, Caen, France

Corresponding Author

Email: cattoir-v@chu-caen.fr

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: FL WvS MS RJLW RL VC. Performed the experiments: FL WvS MS BP RT FLB NV XZ AD. Analyzed the data: FL WvS MS JCG RL VC. Contributed reagents/materials/analysis tools: WvS MS NV RJLW RL VC. Wrote the paper: FL WvS JCG RL VC.