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Research Article

The Ebola Virus Glycoprotein Contributes to but Is Not Sufficient for Virulence In Vivo

  • Allison Groseth,

    Affiliations: Laboratory of Virology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, United States of America, Institut für Virologie, Philipps Universität Marburg, Marburg, Germany, Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba, Canada, Department of Medical Microbiology, University of Manitoba, Winnipeg, Manitoba, Canada

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  • Andrea Marzi,

    Affiliations: Laboratory of Virology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, United States of America, Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba, Canada

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  • Thomas Hoenen,

    Affiliations: Laboratory of Virology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, United States of America, Institut für Virologie, Philipps Universität Marburg, Marburg, Germany, Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba, Canada

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  • Astrid Herwig,

    Affiliation: Institut für Virologie, Philipps Universität Marburg, Marburg, Germany

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  • Don Gardner,

    Affiliation: Rocky Mountain Veterinary Branch, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, United States of America

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  • Stephan Becker,

    Affiliation: Institut für Virologie, Philipps Universität Marburg, Marburg, Germany

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  • Hideki Ebihara,

    Affiliations: Laboratory of Virology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, United States of America, Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba, Canada

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  • Heinz Feldmann mail

    feldmannh@niaid.nih.gov

    Affiliations: Laboratory of Virology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, United States of America, Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba, Canada, Department of Medical Microbiology, University of Manitoba, Winnipeg, Manitoba, Canada

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  • Published: August 02, 2012
  • DOI: 10.1371/journal.ppat.1002847

About the Authors

Allison Groseth, Andrea Marzi, Thomas Hoenen, Hideki Ebihara, Heinz Feldmann
Laboratory of Virology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, United States of America
Allison Groseth, Thomas Hoenen, Astrid Herwig, Stephan Becker
Institut für Virologie, Philipps Universität Marburg, Marburg, Germany
Allison Groseth, Andrea Marzi, Thomas Hoenen, Hideki Ebihara, Heinz Feldmann
Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba, Canada
Allison Groseth, Heinz Feldmann
Department of Medical Microbiology, University of Manitoba, Winnipeg, Manitoba, Canada
Don Gardner
Rocky Mountain Veterinary Branch, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, United States of America

Corresponding Author

Email: feldmannh@niaid.nih.gov

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: AG AM TH HE HF. Performed the experiments: AG AM TH AH DG. Analyzed the data: AG AM TH AH DG SB HE HF. Contributed reagents/materials/analysis tools: AG AM TH DG SB HE HF. Wrote the paper: AG AM TH AH DG SB HE HF.