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Research Article

A Candida Biofilm-Induced Pathway for Matrix Glucan Delivery: Implications for Drug Resistance

  • Heather T. Taff,

    Affiliation: Departments of Medicine and Medical Microbiology and Immunology, University of Wisconsin, Madison, Wisconsin

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  • Jeniel E. Nett,

    Affiliation: Departments of Medicine and Medical Microbiology and Immunology, University of Wisconsin, Madison, Wisconsin

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  • Robert Zarnowski,

    Affiliation: Departments of Medicine and Medical Microbiology and Immunology, University of Wisconsin, Madison, Wisconsin

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  • Kelly M. Ross,

    Affiliation: Departments of Medicine and Medical Microbiology and Immunology, University of Wisconsin, Madison, Wisconsin

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  • Hiram Sanchez,

    Affiliation: Departments of Medicine and Medical Microbiology and Immunology, University of Wisconsin, Madison, Wisconsin

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  • Mike T. Cain,

    Affiliation: Departments of Medicine and Medical Microbiology and Immunology, University of Wisconsin, Madison, Wisconsin

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  • Jessica Hamaker,

    Affiliation: Department of Microbiology, Columbia University, New York, New York

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  • Aaron P. Mitchell,

    Affiliation: Department of Biological Sciences, Carnegie Mellon University, Pittsburgh, Pennsylvania

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  • David R. Andes mail

    dra@medicine.wisc.edu

    Affiliation: Departments of Medicine and Medical Microbiology and Immunology, University of Wisconsin, Madison, Wisconsin

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  • Published: August 02, 2012
  • DOI: 10.1371/journal.ppat.1002848

About the Authors

Heather T. Taff, Jeniel E. Nett, Robert Zarnowski, Kelly M. Ross, Hiram Sanchez, Mike T. Cain, David R. Andes
Departments of Medicine and Medical Microbiology and Immunology, University of Wisconsin, Madison, Wisconsin
Jessica Hamaker
Department of Microbiology, Columbia University, New York, New York
Aaron P. Mitchell
Department of Biological Sciences, Carnegie Mellon University, Pittsburgh, Pennsylvania

Corresponding Author

Email: dra@medicine.wisc.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: HTT JEN APM DRA. Performed the experiments: HTT JEN KMR MTC RZ HS JH APM. Contributed reagents/materials/analysis tools: HTT JEN KMR RZ HS APM DRA. Wrote the paper: HTT JEN APM DRA.