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Research Article

Cytomegalovirus Infection Impairs Immune Responses and Accentuates T-cell Pool Changes Observed in Mice with Aging

  • Luka Cicin-Sain mail,

    luka.cicin-sain@helmholtz-hzi.de (LCS); nikolich@email.arizona.edu (JNZ)

    Affiliations: Department of Vaccinology and Applied Microbiology, Helmholtz Center for Infection Research, Braunschweig, Germany, Vaccine and Gene Therapy Institute and the Oregon National Primate Research Center, Oregon Health and Science University, Portland, Oregon, United States of America

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  • James D. Brien,

    Affiliations: Vaccine and Gene Therapy Institute and the Oregon National Primate Research Center, Oregon Health and Science University, Portland, Oregon, United States of America, Department of Microbiology, Washington University School of Medicine, St. Louis, Missouri, United States of America

    X
  • Jennifer L. Uhrlaub,

    Affiliations: Vaccine and Gene Therapy Institute and the Oregon National Primate Research Center, Oregon Health and Science University, Portland, Oregon, United States of America, Department of Immunobiology and the Arizona Center on Aging, University of Arizona College of Medicine, Tucson, Arizona, United States of America

    X
  • Anja Drabig,

    Affiliation: Department of Vaccinology and Applied Microbiology, Helmholtz Center for Infection Research, Braunschweig, Germany

    X
  • Thomas F. Marandu,

    Affiliation: Department of Vaccinology and Applied Microbiology, Helmholtz Center for Infection Research, Braunschweig, Germany

    X
  • Janko Nikolich-Zugich mail

    luka.cicin-sain@helmholtz-hzi.de (LCS); nikolich@email.arizona.edu (JNZ)

    Affiliations: Vaccine and Gene Therapy Institute and the Oregon National Primate Research Center, Oregon Health and Science University, Portland, Oregon, United States of America, Department of Immunobiology and the Arizona Center on Aging, University of Arizona College of Medicine, Tucson, Arizona, United States of America

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  • Published: August 16, 2012
  • DOI: 10.1371/journal.ppat.1002849

About the Authors

Luka Cicin-Sain, Anja Drabig, Thomas F. Marandu
Department of Vaccinology and Applied Microbiology, Helmholtz Center for Infection Research, Braunschweig, Germany
Luka Cicin-Sain, James D. Brien, Jennifer L. Uhrlaub, Janko Nikolich-Zugich
Vaccine and Gene Therapy Institute and the Oregon National Primate Research Center, Oregon Health and Science University, Portland, Oregon, United States of America
James D. Brien
Department of Microbiology, Washington University School of Medicine, St. Louis, Missouri, United States of America
Jennifer L. Uhrlaub, Janko Nikolich-Zugich
Department of Immunobiology and the Arizona Center on Aging, University of Arizona College of Medicine, Tucson, Arizona, United States of America

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: LCS JDB JNZ. Performed the experiments: LCS JDB JLU AD TFM. Analyzed the data: LCS JLU JNZ. Wrote the paper: LCS JNZ.