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Research Article

Clonality Despite Sex: The Evolution of Host-Associated Sexual Neighborhoods in the Pathogenic Fungus Penicillium marneffei

  • Daniel A. Henk mail,

    d.henk@imperial.ac.uk

    Affiliation: Department of Infectious Disease Epidemiology, Imperial College, Norfolk Place, London, United Kingdom

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  • Revital Shahar-Golan,

    Affiliation: Department of Infectious Disease Epidemiology, Imperial College, Norfolk Place, London, United Kingdom

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  • Khuraijam Ranjana Devi,

    Affiliation: Departments of Microbiology, Regional Institute of Medical Sciences, Imphal, Manipur, India

    X
  • Kylie J. Boyce,

    Affiliation: Department of Genetics, University of Melbourne, Victoria, Australia

    X
  • Nengyong Zhan,

    Affiliation: The Third People's Hospital, Shenzhen City, Guangdong Province, China

    X
  • Natalie D. Fedorova,

    Affiliation: The J. Craig Venter Institute, Rockville, Maryland, United States of America

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  • William C. Nierman,

    Affiliation: The J. Craig Venter Institute, Rockville, Maryland, United States of America

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  • Po-Ren Hsueh,

    Affiliation: Departments of Laboratory Medicine and Internal Medicine, National Taiwan University Hospital, National Taiwan University College of Medicine, Taipei, Taiwan, Republic of China

    X
  • Kwok-Yung Yuen,

    Affiliation: Department of Microbiology, The University of Hong Kong, Queen Mary Hospital, Hong Kong Island, Hong Kong

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  • Tran P. M. Sieu,

    Affiliation: Hospital for Tropical Diseases, Ho Chi Minh City, Viet Nam

    X
  • Nguyen Van Kinh,

    Affiliation: National Hospital for Tropical Diseases, Ha Noi, Viet Nam

    X
  • Heiman Wertheim,

    Affiliation: Oxford University Clinical Research Unit, Wellcome Trust Major Overseas Program Viet Nam National Hospital for Tropical Diseases, Ha Noi, Viet Nam

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  • Stephen G. Baker,

    Affiliation: Oxford University Clinical Research Unit, Wellcome Trust Major Overseas Programme Viet Nam Hospital for Tropical Diseases, Ho Chi Minh City, Viet Nam

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  • Jeremy N. Day,

    Affiliation: Oxford University Clinical Research Unit, Wellcome Trust Major Overseas Programme Viet Nam Hospital for Tropical Diseases, Ho Chi Minh City, Viet Nam

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  • Nongnuch Vanittanakom,

    Affiliation: Department of Microbiology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand

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  • Elaine M. Bignell,

    Affiliation: Department of Microbiology, Imperial College London, London, United Kingdom

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  • Alex Andrianopoulos,

    Affiliation: Department of Genetics, University of Melbourne, Victoria, Australia

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  • Matthew C. Fisher

    Affiliation: Department of Infectious Disease Epidemiology, Imperial College, Norfolk Place, London, United Kingdom

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  • Published: October 04, 2012
  • DOI: 10.1371/journal.ppat.1002851

About the Authors

Daniel A. Henk, Revital Shahar-Golan, Matthew C. Fisher
Department of Infectious Disease Epidemiology, Imperial College, Norfolk Place, London, United Kingdom
Khuraijam Ranjana Devi
Departments of Microbiology, Regional Institute of Medical Sciences, Imphal, Manipur, India
Kylie J. Boyce, Alex Andrianopoulos
Department of Genetics, University of Melbourne, Victoria, Australia
Nengyong Zhan
The Third People's Hospital, Shenzhen City, Guangdong Province, China
Natalie D. Fedorova, William C. Nierman
The J. Craig Venter Institute, Rockville, Maryland, United States of America
Po-Ren Hsueh
Departments of Laboratory Medicine and Internal Medicine, National Taiwan University Hospital, National Taiwan University College of Medicine, Taipei, Taiwan, Republic of China
Kwok-Yung Yuen
Department of Microbiology, The University of Hong Kong, Queen Mary Hospital, Hong Kong Island, Hong Kong
Tran P. M. Sieu
Hospital for Tropical Diseases, Ho Chi Minh City, Viet Nam
Nguyen Van Kinh
National Hospital for Tropical Diseases, Ha Noi, Viet Nam
Heiman Wertheim
Oxford University Clinical Research Unit, Wellcome Trust Major Overseas Program Viet Nam National Hospital for Tropical Diseases, Ha Noi, Viet Nam
Stephen G. Baker, Jeremy N. Day
Oxford University Clinical Research Unit, Wellcome Trust Major Overseas Programme Viet Nam Hospital for Tropical Diseases, Ho Chi Minh City, Viet Nam
Nongnuch Vanittanakom
Department of Microbiology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand
Elaine M. Bignell
Department of Microbiology, Imperial College London, London, United Kingdom

Corresponding Author

Email: d.henk@imperial.ac.uk

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: DAH MCF. Performed the experiments: DAH RS-G KRD KJB NDF SGB. Analyzed the data: DAH RS-G KRD KJB MCF. Contributed reagents/materials/analysis tools: DAH KJB NZ NDF WCN P-RH K-YY TPMS NVK HW SGB JND NV EMB AA MCF. Wrote the paper: DAH MCF.