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Research Article

A Novel Virulence Strategy for Pseudomonas aeruginosa Mediated by an Autotransporter with Arginine-Specific Aminopeptidase Activity

  • Jeni C. A. Luckett equal contributor,

    equal contributor Contributed equally to this work with: Jeni C. A. Luckett, Owen Darch

    Affiliation: School of Molecular Medical Sciences, Centre for Biomolecular Sciences, University of Nottingham, University Park, Nottingham, United Kingdom

    X
  • Owen Darch equal contributor,

    equal contributor Contributed equally to this work with: Jeni C. A. Luckett, Owen Darch

    Affiliation: School of Molecular Medical Sciences, Centre for Biomolecular Sciences, University of Nottingham, University Park, Nottingham, United Kingdom

    X
  • Chase Watters,

    Affiliation: Department of Surgery, MS 8312, Texas Tech University Health Sciences Center, Lubbock, Texas, United States of America

    X
  • Manal AbuOun,

    Affiliation: Department of Bacteriology, Animal Health and Veterinary Laboratories Agency (Weybridge), Addlestone, Surrey, United Kingdom

    X
  • Victoria Wright,

    Affiliation: School of Molecular Medical Sciences, Centre for Biomolecular Sciences, University of Nottingham, University Park, Nottingham, United Kingdom

    X
  • Esteban Paredes-Osses,

    Affiliation: School of Molecular Medical Sciences, Centre for Biomolecular Sciences, University of Nottingham, University Park, Nottingham, United Kingdom

    X
  • Jenny Ward,

    Affiliation: School of Molecular Medical Sciences, Centre for Biomolecular Sciences, University of Nottingham, University Park, Nottingham, United Kingdom

    X
  • Hana Goto,

    Affiliation: School of Molecular Medical Sciences, Centre for Biomolecular Sciences, University of Nottingham, University Park, Nottingham, United Kingdom

    Current address: Department of Orthopaedic Surgery, Columbia University Medical Center, New York, New York, United States of America

    X
  • Stephan Heeb,

    Affiliation: School of Molecular Medical Sciences, Centre for Biomolecular Sciences, University of Nottingham, University Park, Nottingham, United Kingdom

    X
  • Stéphanie Pommier,

    Affiliation: School of Molecular Medical Sciences, Centre for Biomolecular Sciences, University of Nottingham, University Park, Nottingham, United Kingdom

    Current address: DESP (Département de l'Evaluation et du Suivi des Programmes), INSERM, Paris, France

    X
  • Kendra P. Rumbaugh,

    Affiliation: Department of Surgery, MS 8312, Texas Tech University Health Sciences Center, Lubbock, Texas, United States of America

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  • Miguel Cámara,

    Affiliation: School of Molecular Medical Sciences, Centre for Biomolecular Sciences, University of Nottingham, University Park, Nottingham, United Kingdom

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  • Kim R. Hardie mail

    kim.hardie@nottingham.ac.uk

    Affiliation: School of Molecular Medical Sciences, Centre for Biomolecular Sciences, University of Nottingham, University Park, Nottingham, United Kingdom

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  • Published: August 23, 2012
  • DOI: 10.1371/journal.ppat.1002854

About the Authors

Jeni C. A. Luckett, Owen Darch, Victoria Wright, Esteban Paredes-Osses, Jenny Ward, Hana Goto, Stephan Heeb, Stéphanie Pommier, Miguel Cámara, Kim R. Hardie
School of Molecular Medical Sciences, Centre for Biomolecular Sciences, University of Nottingham, University Park, Nottingham, United Kingdom
Chase Watters, Kendra P. Rumbaugh
Department of Surgery, MS 8312, Texas Tech University Health Sciences Center, Lubbock, Texas, United States of America
Manal AbuOun
Department of Bacteriology, Animal Health and Veterinary Laboratories Agency (Weybridge), Addlestone, Surrey, United Kingdom

Corresponding Author

Email: kim.hardie@nottingham.ac.uk

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: KRH MC OD SH SP KPR MA. Performed the experiments: JCAL OD CW MA EPO VW JW HG. Analyzed the data: KRH MC OD JCAL SH SP KPR EPO. Contributed reagents/materials/analysis tools: KRH MC KPR MA. Wrote the paper: KRH OD MC.