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Research Article

The HSV-1 Exonuclease, UL12, Stimulates Recombination by a Single Strand Annealing Mechanism

  • April J. Schumacher,

    Affiliation: Molecular, Microbial and Structural Biology Department, University of Connecticut Health Center, Farmington, Connecticut, United States of America

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  • Kareem N. Mohni,

    Affiliation: Molecular, Microbial and Structural Biology Department, University of Connecticut Health Center, Farmington, Connecticut, United States of America

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  • Yinan Kan,

    Affiliation: Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota Medical School, Minneapolis, Minnesota, United States of America

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  • Eric A. Hendrickson,

    Affiliation: Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota Medical School, Minneapolis, Minnesota, United States of America

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  • Jeremy M. Stark,

    Affiliation: Department of Cancer Biology, Beckman Research Institute of the City of Hope, Duarte, California, United States of America

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  • Sandra K. Weller mail

    weller@nso2.uchc.edu

    Affiliation: Molecular, Microbial and Structural Biology Department, University of Connecticut Health Center, Farmington, Connecticut, United States of America

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  • Published: August 09, 2012
  • DOI: 10.1371/journal.ppat.1002862

About the Authors

April J. Schumacher, Kareem N. Mohni, Sandra K. Weller
Molecular, Microbial and Structural Biology Department, University of Connecticut Health Center, Farmington, Connecticut, United States of America
Yinan Kan, Eric A. Hendrickson
Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota Medical School, Minneapolis, Minnesota, United States of America
Jeremy M. Stark
Department of Cancer Biology, Beckman Research Institute of the City of Hope, Duarte, California, United States of America

Corresponding Author

Email: weller@nso2.uchc.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: AJS KNM YK EAH JMS SKW. Performed the experiments: AJS KNM YK. Analyzed the data: AJS KNM SKW. Contributed reagents/materials/analysis tools: AJS YK EAH JMS. Wrote the paper: AJS SKW.