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Research Article

Convergent Evolution of Argonaute-2 Slicer Antagonism in Two Distinct Insect RNA Viruses

  • Joël T. van Mierlo,

    Affiliation: Department of Medical Microbiology, Radboud University Nijmegen Medical Centre, Nijmegen Centre for Molecular Life Sciences, Nijmegen Institute for Infection, Inflammation and Immunity, Nijmegen, The Netherlands

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  • Alfred W. Bronkhorst,

    Affiliation: Department of Medical Microbiology, Radboud University Nijmegen Medical Centre, Nijmegen Centre for Molecular Life Sciences, Nijmegen Institute for Infection, Inflammation and Immunity, Nijmegen, The Netherlands

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  • Gijs J. Overheul,

    Affiliation: Department of Medical Microbiology, Radboud University Nijmegen Medical Centre, Nijmegen Centre for Molecular Life Sciences, Nijmegen Institute for Infection, Inflammation and Immunity, Nijmegen, The Netherlands

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  • Sajna A. Sadanandan,

    Affiliation: Department of Molecular Biology, Umeå University, Umeå, Sweden

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  • Jens-Ola Ekström,

    Affiliation: Department of Molecular Biology, Umeå University, Umeå, Sweden

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  • Marco Heestermans,

    Affiliation: Department of Medical Microbiology, Radboud University Nijmegen Medical Centre, Nijmegen Centre for Molecular Life Sciences, Nijmegen Institute for Infection, Inflammation and Immunity, Nijmegen, The Netherlands

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  • Dan Hultmark,

    Affiliations: Department of Molecular Biology, Umeå University, Umeå, Sweden, Institute of Biomedical Technology, University of Tampere, Tampere, Finland

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  • Christophe Antoniewski,

    Affiliation: Drosophila Genetics and Epigenetics, Université Pierre et Marie Curie Paris VI, CNRS UMR 7622 - Biologie du Développement, Paris, France

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  • Ronald P. van Rij mail

    r.vanrij@ncmls.ru.nl

    Affiliation: Department of Medical Microbiology, Radboud University Nijmegen Medical Centre, Nijmegen Centre for Molecular Life Sciences, Nijmegen Institute for Infection, Inflammation and Immunity, Nijmegen, The Netherlands

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  • Published: August 16, 2012
  • DOI: 10.1371/journal.ppat.1002872

About the Authors

Joël T. van Mierlo, Alfred W. Bronkhorst, Gijs J. Overheul, Marco Heestermans, Ronald P. van Rij
Department of Medical Microbiology, Radboud University Nijmegen Medical Centre, Nijmegen Centre for Molecular Life Sciences, Nijmegen Institute for Infection, Inflammation and Immunity, Nijmegen, The Netherlands
Sajna A. Sadanandan, Jens-Ola Ekström, Dan Hultmark
Department of Molecular Biology, Umeå University, Umeå, Sweden
Dan Hultmark
Institute of Biomedical Technology, University of Tampere, Tampere, Finland
Christophe Antoniewski
Drosophila Genetics and Epigenetics, Université Pierre et Marie Curie Paris VI, CNRS UMR 7622 - Biologie du Développement, Paris, France

Corresponding Author

Email: r.vanrij@ncmls.ru.nl

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: JTvM CA RPvR. Performed the experiments: JTvM AWB GJO SAS JE MH. Analyzed the data: JTvM AWB CA RPvR. Contributed reagents/materials/analysis tools: SAS JE DH. Wrote the paper: JTvM RPvR. Bioinformatic analyses: CA. Edited the manuscript: JTvM JE DH CA RPvR.