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Research Article

A Unique Bivalent Binding and Inhibition Mechanism by the Yatapoxvirus Interleukin 18 Binding Protein

  • Brian Krumm,

    Affiliation: Department of Biochemistry and Molecular Biology, Oklahoma State University, Stillwater, Oklahoma, United States of America

    X
  • Xiangzhi Meng,

    Affiliation: Department of Microbiology and Immunology, University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States of America

    X
  • Zhixin Wang,

    Affiliation: Department of Biochemistry and Molecular Biology, Oklahoma State University, Stillwater, Oklahoma, United States of America

    X
  • Yan Xiang equal contributor mail,

    equal contributor Contributed equally to this work with: Yan Xiang, Junpeng Deng

    xiangy@uthscsa.edu (YX); Junpeng.deng@okstate.edu (JD)

    Affiliation: Department of Microbiology and Immunology, University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States of America

    X
  • Junpeng Deng equal contributor mail

    equal contributor Contributed equally to this work with: Yan Xiang, Junpeng Deng

    xiangy@uthscsa.edu (YX); Junpeng.deng@okstate.edu (JD)

    Affiliation: Department of Biochemistry and Molecular Biology, Oklahoma State University, Stillwater, Oklahoma, United States of America

    X
  • Published: August 23, 2012
  • DOI: 10.1371/journal.ppat.1002876

About the Authors

Brian Krumm, Zhixin Wang, Junpeng Deng
Department of Biochemistry and Molecular Biology, Oklahoma State University, Stillwater, Oklahoma, United States of America
Xiangzhi Meng, Yan Xiang
Department of Microbiology and Immunology, University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States of America

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: YX JD. Performed the experiments: BK XM ZW YX JD. Analyzed the data: BK YX JD. Wrote the paper: BK YX JD.