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Research Article

Inhibition of Candida parapsilosis Fatty Acid Synthase (Fas2) Induces Mitochondrial Cell Death in Serum

  • Long Nam Nguyen mail,

    ngnlong@gmail.com (LNN); josh.nosanchuk@einstein.yu.edu (JDN)

    Affiliations: Department of Medicine (Division of Infectious Diseases), Albert Einstein College of Medicine, New York, New York, United States of America, Signature Research Program in Cardiovascular & Metabolic Disorders, DUKE-NUS Graduate Medical School, Singapore

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  • Gabriele Vargas Cesar,

    Affiliation: Laboratório de Estudos Integrados em Bioquímica Microbiana, Instituto de Microbiologia Professor Paulo de Góes, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil

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  • Giang Thi Thu Le,

    Affiliation: University of Hamburg, Biocenter Klein Flottbek, Department of Molecular Phytopathology and Genetics, Hamburg, Germany

    Current address: Singapore Immunological Networks, A*STAR, Singapore.

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  • David L. Silver,

    Affiliation: Signature Research Program in Cardiovascular & Metabolic Disorders, DUKE-NUS Graduate Medical School, Singapore

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  • Leonardo Nimrichter,

    Affiliation: Laboratório de Estudos Integrados em Bioquímica Microbiana, Instituto de Microbiologia Professor Paulo de Góes, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil

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  • Joshua D. Nosanchuk mail

    ngnlong@gmail.com (LNN); josh.nosanchuk@einstein.yu.edu (JDN)

    Affiliations: Department of Medicine (Division of Infectious Diseases), Albert Einstein College of Medicine, New York, New York, United States of America, Department of Microbiology and Immunology, Albert Einstein College of Medicine, New York, New York, United States of America

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  • Published: August 30, 2012
  • DOI: 10.1371/journal.ppat.1002879

About the Authors

Long Nam Nguyen, Joshua D. Nosanchuk
Department of Medicine (Division of Infectious Diseases), Albert Einstein College of Medicine, New York, New York, United States of America
Long Nam Nguyen, David L. Silver
Signature Research Program in Cardiovascular & Metabolic Disorders, DUKE-NUS Graduate Medical School, Singapore
Gabriele Vargas Cesar, Leonardo Nimrichter
Laboratório de Estudos Integrados em Bioquímica Microbiana, Instituto de Microbiologia Professor Paulo de Góes, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil
Giang Thi Thu Le
University of Hamburg, Biocenter Klein Flottbek, Department of Molecular Phytopathology and Genetics, Hamburg, Germany
Joshua D. Nosanchuk
Department of Microbiology and Immunology, Albert Einstein College of Medicine, New York, New York, United States of America

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: L. Nguyen. Performed the experiments: L. Nguyen, G. Cesar, G. Le. Analyzed the data: L. Nguyen, J. Nosanchuk. Contributed reagents/materials/analysis tools: J. Nosanchuk, L. Nimrichter, D. Silver. Wrote the paper: L. Nguyen.