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Research Article

Elucidation of Hepatitis C Virus Transmission and Early Diversification by Single Genome Sequencing

  • Hui Li,

    Affiliation: Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

    X
  • Mark B. Stoddard,

    Affiliation: Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

    X
  • Shuyi Wang,

    Affiliation: Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

    X
  • Lily M. Blair,

    Affiliation: Santa Fe Institute, Santa Fe, New Mexico, United States of America

    X
  • Elena E. Giorgi,

    Affiliations: Theoretical Division, Los Alamos National Laboratory, Los Alamos, New Mexico, United States of America, Center for Nonlinear Studies, Los Alamos National Laboratory, Los Alamos, New Mexico, United States of America

    X
  • Erica H. Parrish,

    Affiliation: Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

    X
  • Gerald H. Learn,

    Affiliation: Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

    X
  • Peter Hraber,

    Affiliation: Theoretical Division, Los Alamos National Laboratory, Los Alamos, New Mexico, United States of America

    X
  • Paul A. Goepfert,

    Affiliation: University of Alabama at Birmingham, Birmingham, Alabama, United States of America

    X
  • Michael S. Saag,

    Affiliation: University of Alabama at Birmingham, Birmingham, Alabama, United States of America

    X
  • Thomas N. Denny,

    Affiliation: Duke University School of Medicine, Durham, North Carolina, United States of America

    X
  • Barton F. Haynes,

    Affiliation: Duke University School of Medicine, Durham, North Carolina, United States of America

    X
  • Beatrice H. Hahn,

    Affiliation: Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

    X
  • Ruy M. Ribeiro,

    Affiliation: Theoretical Division, Los Alamos National Laboratory, Los Alamos, New Mexico, United States of America

    X
  • Alan S. Perelson,

    Affiliation: Theoretical Division, Los Alamos National Laboratory, Los Alamos, New Mexico, United States of America

    X
  • Bette T. Korber,

    Affiliations: Santa Fe Institute, Santa Fe, New Mexico, United States of America, Theoretical Division, Los Alamos National Laboratory, Los Alamos, New Mexico, United States of America

    X
  • Tanmoy Bhattacharya,

    Affiliations: Santa Fe Institute, Santa Fe, New Mexico, United States of America, Theoretical Division, Los Alamos National Laboratory, Los Alamos, New Mexico, United States of America

    X
  • George M. Shaw mail

    shawg@upenn.edu

    Affiliation: Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

    X
  • Published: August 23, 2012
  • DOI: 10.1371/journal.ppat.1002880

About the Authors

Hui Li, Mark B. Stoddard, Shuyi Wang, Erica H. Parrish, Gerald H. Learn, Beatrice H. Hahn, George M. Shaw
Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
Lily M. Blair, Bette T. Korber, Tanmoy Bhattacharya
Santa Fe Institute, Santa Fe, New Mexico, United States of America
Elena E. Giorgi, Peter Hraber, Ruy M. Ribeiro, Alan S. Perelson, Bette T. Korber, Tanmoy Bhattacharya
Theoretical Division, Los Alamos National Laboratory, Los Alamos, New Mexico, United States of America
Elena E. Giorgi
Center for Nonlinear Studies, Los Alamos National Laboratory, Los Alamos, New Mexico, United States of America
Paul A. Goepfert, Michael S. Saag
University of Alabama at Birmingham, Birmingham, Alabama, United States of America
Thomas N. Denny, Barton F. Haynes
Duke University School of Medicine, Durham, North Carolina, United States of America

Corresponding Author

Email: shawg@upenn.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: HL LMB EEG PAG MSS TND BFH BHH RMR ASP BTK TB GMS. Performed the experiments: HL MBS SW EHP. Analyzed the data: HL LMB EEG GHL PH BHH RMR ASP BTK TB GMS. Contributed reagents/materials/analysis tools: LMB EEG PAG MSS TND BFH RMR ASP BTK TB. Wrote the paper: HL MBS SW LMB EEG EHP GHL PH PAG MSS TND BFH BHH RMR ASP BTK TB GMS.