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Research Article

Upregulation of Retinal Dehydrogenase 2 in Alternatively Activated Macrophages during Retinoid-dependent Type-2 Immunity to Helminth Infection in Mice

  • Mara J. Broadhurst,

    Affiliation: Division of Experimental Medicine, Department of Medicine, University of California San Francisco, San Francisco, California, United States of America

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  • Jacqueline M. Leung,

    Affiliation: Division of Medical Parasitology, Department of Microbiology, New York University Langone Medical Center, New York, New York, United States of America

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  • K. C. Lim,

    Affiliation: Center for Discovery and Innovation in Parasitic Diseases, Department of Pathology, University of California San Francisco, San Francisco, California, United States of America

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  • Natasha M. Girgis,

    Affiliation: Division of Medical Parasitology, Department of Microbiology, New York University Langone Medical Center, New York, New York, United States of America

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  • Uma Mahesh Gundra,

    Affiliation: Division of Medical Parasitology, Department of Microbiology, New York University Langone Medical Center, New York, New York, United States of America

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  • Padraic G. Fallon,

    Affiliation: Institute of Molecular Medicine, School of Medicine, Trinity College, Dublin, Ireland

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  • Mary Premenko-Lanier,

    Affiliation: Division of Experimental Medicine, Department of Medicine, University of California San Francisco, San Francisco, California, United States of America

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  • James H. McKerrow,

    Affiliation: Center for Discovery and Innovation in Parasitic Diseases, Department of Pathology, University of California San Francisco, San Francisco, California, United States of America

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  • Joseph M. McCune,

    Affiliation: Division of Experimental Medicine, Department of Medicine, University of California San Francisco, San Francisco, California, United States of America

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  • P'ng Loke mail

    Png.loke@nyumc.org

    Affiliation: Division of Medical Parasitology, Department of Microbiology, New York University Langone Medical Center, New York, New York, United States of America

    X
  • Published: August 23, 2012
  • DOI: 10.1371/journal.ppat.1002883

About the Authors

Mara J. Broadhurst, Mary Premenko-Lanier, Joseph M. McCune
Division of Experimental Medicine, Department of Medicine, University of California San Francisco, San Francisco, California, United States of America
Jacqueline M. Leung, Natasha M. Girgis, Uma Mahesh Gundra, P'ng Loke
Division of Medical Parasitology, Department of Microbiology, New York University Langone Medical Center, New York, New York, United States of America
K. C. Lim, James H. McKerrow
Center for Discovery and Innovation in Parasitic Diseases, Department of Pathology, University of California San Francisco, San Francisco, California, United States of America
Padraic G. Fallon
Institute of Molecular Medicine, School of Medicine, Trinity College, Dublin, Ireland

Corresponding Author

Email: Png.loke@nyumc.org

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: MJB NMG UMG JMM PL JHM MPL. Performed the experiments: MJB JML KCL NMG UMG PL. Analyzed the data: MJB JML NMG UMG PGF PL. Contributed reagents/materials/analysis tools: KCL MPL JHM JMM. Wrote the paper: MJB JMM PL.