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Research Article

Protease Cleavage Leads to Formation of Mature Trimer Interface in HIV-1 Capsid

  • Xin Meng equal contributor,

    equal contributor Contributed equally to this work with: Xin Meng, Gongpu Zhao, Ernest Yufenyuy

    Affiliation: Department of Structural Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America

    X
  • Gongpu Zhao equal contributor,

    equal contributor Contributed equally to this work with: Xin Meng, Gongpu Zhao, Ernest Yufenyuy

    Affiliation: Department of Structural Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America

    X
  • Ernest Yufenyuy equal contributor,

    equal contributor Contributed equally to this work with: Xin Meng, Gongpu Zhao, Ernest Yufenyuy

    Affiliation: Department of Pathology, Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America

    X
  • Danxia Ke,

    Affiliation: Department of Structural Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America

    X
  • Jiying Ning,

    Affiliation: Department of Structural Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America

    X
  • Maria DeLucia,

    Affiliation: Department of Structural Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America

    X
  • Jinwoo Ahn,

    Affiliation: Department of Structural Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America

    X
  • Angela M. Gronenborn,

    Affiliation: Department of Structural Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America

    X
  • Christopher Aiken mail,

    chris.aiken@vanderbilt.edu (CA); pez7@pitt.edu (PZ)

    Affiliation: Department of Pathology, Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America

    X
  • Peijun Zhang mail

    chris.aiken@vanderbilt.edu (CA); pez7@pitt.edu (PZ)

    Affiliation: Department of Structural Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America

    X
  • Published: August 23, 2012
  • DOI: 10.1371/journal.ppat.1002886

About the Authors

Xin Meng, Gongpu Zhao, Danxia Ke, Jiying Ning, Maria DeLucia, Jinwoo Ahn, Angela M. Gronenborn, Peijun Zhang
Department of Structural Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America
Ernest Yufenyuy, Christopher Aiken
Department of Pathology, Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: PZ CA. Performed the experiments: XM GZ EY DK JN MD. Analyzed the data: XM GZ EY JA CA PZ. Contributed reagents/materials/analysis tools: XM GZ EY JA CA PZ. Wrote the paper: XM GZ AMG CA PZ.