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Research Article

ADCC Develops Over Time during Persistent Infection with Live-Attenuated SIV and Is Associated with Complete Protection against SIVmac251 Challenge

  • Michael D. Alpert,

    Affiliation: Department of Microbiology and Immunobiology, Harvard Medical School, New England Primate Research Center, Southborough, Massachusetts, United States of America

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  • Jackson D. Harvey,

    Affiliation: Department of Microbiology and Immunobiology, Harvard Medical School, New England Primate Research Center, Southborough, Massachusetts, United States of America

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  • W. Anderson Lauer,

    Affiliation: Department of Microbiology and Immunobiology, Harvard Medical School, New England Primate Research Center, Southborough, Massachusetts, United States of America

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  • R. Keith Reeves,

    Affiliation: Immunology Division, Harvard Medical School, New England Primate Research Center, Southborough, Massachusetts, United States of America

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  • Michael Piatak Jr.,

    Affiliation: SAIC Frederick, National Cancer Institute at Frederick, Frederick, Maryland, United States of America

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  • Angela Carville,

    Affiliation: Department of Pathology, Harvard Medical School, New England Primate Research Center, Southborough, Massachusetts, United States of America

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  • Keith G. Mansfield,

    Affiliation: Department of Pathology, Harvard Medical School, New England Primate Research Center, Southborough, Massachusetts, United States of America

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  • Jeffrey D. Lifson,

    Affiliation: SAIC Frederick, National Cancer Institute at Frederick, Frederick, Maryland, United States of America

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  • Wenjun Li,

    Affiliation: University of Massachusetts Medical School, Worcester, Massachusetts, United States of America

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  • Ronald C. Desrosiers,

    Affiliation: Department of Microbiology and Immunobiology, Harvard Medical School, New England Primate Research Center, Southborough, Massachusetts, United States of America

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  • R. Paul Johnson,

    Affiliations: Immunology Division, Harvard Medical School, New England Primate Research Center, Southborough, Massachusetts, United States of America, Ragon Institute of Massachusetts General Hospital, MIT, and Harvard, and Infectious Disease Unit, Massachusetts General Hospital, Boston, Massachusetts, United States of America

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  • David T. Evans mail

    david_evans@hms.harvard.edu

    Affiliation: Department of Microbiology and Immunobiology, Harvard Medical School, New England Primate Research Center, Southborough, Massachusetts, United States of America

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  • Published: August 23, 2012
  • DOI: 10.1371/journal.ppat.1002890

About the Authors

Michael D. Alpert, Jackson D. Harvey, W. Anderson Lauer, Ronald C. Desrosiers, David T. Evans
Department of Microbiology and Immunobiology, Harvard Medical School, New England Primate Research Center, Southborough, Massachusetts, United States of America
R. Keith Reeves, R. Paul Johnson
Immunology Division, Harvard Medical School, New England Primate Research Center, Southborough, Massachusetts, United States of America
Michael Piatak Jr., Jeffrey D. Lifson
SAIC Frederick, National Cancer Institute at Frederick, Frederick, Maryland, United States of America
Angela Carville, Keith G. Mansfield
Department of Pathology, Harvard Medical School, New England Primate Research Center, Southborough, Massachusetts, United States of America
Wenjun Li
University of Massachusetts Medical School, Worcester, Massachusetts, United States of America
R. Paul Johnson
Ragon Institute of Massachusetts General Hospital, MIT, and Harvard, and Infectious Disease Unit, Massachusetts General Hospital, Boston, Massachusetts, United States of America

Corresponding Author

Email: david_evans@hms.harvard.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: MDA RKR RCD RPJ DTE. Performed the experiments: MDA JDH. Analyzed the data: MDA WL RPJ RCD DTE. Wrote the paper: MDA DTE. Provided technical assistance: WAL. Performed the viral load measurements: MP JDL. Performed veterinary procedures: AC KGM.