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Research Article

Human Monoclonal Antibody HCV1 Effectively Prevents and Treats HCV Infection in Chimpanzees

  • Trevor J. Morin equal contributor,

    equal contributor Contributed equally to this work with: Trevor J. Morin, Teresa J. Broering

    Affiliation: MassBiologics, University of Massachusetts Medical School, Boston, Massachusetts, United States of America

    Current address: Department of Biomolecular Engineering, University of California Santa Cruz, Santa Cruz, California, United States of America.

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  • Teresa J. Broering equal contributor,

    equal contributor Contributed equally to this work with: Trevor J. Morin, Teresa J. Broering

    Affiliation: MassBiologics, University of Massachusetts Medical School, Boston, Massachusetts, United States of America

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  • Brett A. Leav,

    Affiliation: MassBiologics, University of Massachusetts Medical School, Boston, Massachusetts, United States of America

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  • Barbra M. Blair,

    Affiliation: MassBiologics, University of Massachusetts Medical School, Boston, Massachusetts, United States of America

    Current address: Division of Infectious Diseases, Mount Auburn Hospital, Cambridge, Massachusetts, United States of America, and Harvard Medical School, Boston, Massachusetts, United States of America.

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  • Kirk J. Rowley,

    Affiliation: MassBiologics, University of Massachusetts Medical School, Boston, Massachusetts, United States of America

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  • Elisabeth N. Boucher,

    Affiliation: MassBiologics, University of Massachusetts Medical School, Boston, Massachusetts, United States of America

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  • Yang Wang,

    Affiliation: MassBiologics, University of Massachusetts Medical School, Boston, Massachusetts, United States of America

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  • Peter S. Cheslock,

    Affiliation: MassBiologics, University of Massachusetts Medical School, Boston, Massachusetts, United States of America

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  • Michael Knauber,

    Affiliation: MassBiologics, University of Massachusetts Medical School, Boston, Massachusetts, United States of America

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  • David B. Olsen,

    Affiliation: Merck Research Laboratories, West Point, Pennsylvania, United States of America

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  • Steve W. Ludmerer,

    Affiliation: Merck Research Laboratories, West Point, Pennsylvania, United States of America

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  • Gyongyi Szabo,

    Affiliation: Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America

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  • Robert W. Finberg,

    Affiliation: Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America

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  • Robert H. Purcell,

    Affiliation: National Institutes of Health, Bethesda, Maryland, United States of America

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  • Robert E. Lanford,

    Affiliation: Department of Virology and Immunology, Texas Biomedical Research Institute and Southwest National Primate Research Center, San Antonio, Texas, United States of America

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  • Donna M. Ambrosino,

    Affiliation: MassBiologics, University of Massachusetts Medical School, Boston, Massachusetts, United States of America

    Current address: Visterra, Inc., Cambridge, Massachusetts, United States of America.

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  • Deborah C. Molrine,

    Affiliation: MassBiologics, University of Massachusetts Medical School, Boston, Massachusetts, United States of America

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  • Gregory J. Babcock mail

    greg.babcock@umassmed.edu

    Affiliation: MassBiologics, University of Massachusetts Medical School, Boston, Massachusetts, United States of America

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  • Published: August 30, 2012
  • DOI: 10.1371/journal.ppat.1002895

About the Authors

Trevor J. Morin, Teresa J. Broering, Brett A. Leav, Barbra M. Blair, Kirk J. Rowley, Elisabeth N. Boucher, Yang Wang, Peter S. Cheslock, Michael Knauber, Donna M. Ambrosino, Deborah C. Molrine, Gregory J. Babcock
MassBiologics, University of Massachusetts Medical School, Boston, Massachusetts, United States of America
David B. Olsen, Steve W. Ludmerer
Merck Research Laboratories, West Point, Pennsylvania, United States of America
Gyongyi Szabo, Robert W. Finberg
Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America
Robert H. Purcell
National Institutes of Health, Bethesda, Maryland, United States of America
Robert E. Lanford
Department of Virology and Immunology, Texas Biomedical Research Institute and Southwest National Primate Research Center, San Antonio, Texas, United States of America

Corresponding Author

Email: greg.babcock@umassmed.edu

Competing Interests

Drs. Broering, Ambrosino and Babcock are named as coinventors on relevant patents with all rights or royalties assigned to MassBiologics. DBO and SWL are employees of Merck Research Laboratories. This does not alter our adherence to all PLoS Pathogens policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: TJM TJB BAL BMB YW DBO SWL GS RWF RHP REL DMA DCM GJB. Performed the experiments: TJM TJB KJR ENB PSC MK GJB. Analyzed the data: TJM TJB BAL BMB DBO SWL REL DMA DCM GJB. Contributed reagents/materials/analysis tools: DBO RHP REL. Wrote the paper: TJB GJB.