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Research Article

CPSF6 Defines a Conserved Capsid Interface that Modulates HIV-1 Replication

  • Amanda J. Price equal contributor,

    equal contributor Contributed equally to this work with: Amanda J. Price, Adam J. Fletcher

    Affiliation: Medical Research Council Laboratory of Molecular Biology, Division of Protein and Nucleic Acid Chemistry, Cambridge, United Kingdom

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  • Adam J. Fletcher equal contributor,

    equal contributor Contributed equally to this work with: Amanda J. Price, Adam J. Fletcher

    Affiliation: Medical Research Council Centre for Medical Molecular Virology, Division of Infection and Immunity, University College London, London, United Kingdom

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  • Torsten Schaller,

    Affiliation: Medical Research Council Centre for Medical Molecular Virology, Division of Infection and Immunity, University College London, London, United Kingdom

    Current address: Department of Infectious Diseases, King's College London, Guy's Hospital, London, United Kingdom.

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  • Tom Elliott,

    Affiliation: Medical Research Council Laboratory of Molecular Biology, Division of Protein and Nucleic Acid Chemistry, Cambridge, United Kingdom

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  • KyeongEun Lee,

    Affiliation: HIV Drug Resistance Program, National Cancer Institute, Frederick, Maryland, United States of America

    X
  • Vineet N. KewalRamani,

    Affiliation: HIV Drug Resistance Program, National Cancer Institute, Frederick, Maryland, United States of America

    X
  • Jason W. Chin,

    Affiliation: Medical Research Council Laboratory of Molecular Biology, Division of Protein and Nucleic Acid Chemistry, Cambridge, United Kingdom

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  • Greg J. Towers,

    Affiliation: Medical Research Council Centre for Medical Molecular Virology, Division of Infection and Immunity, University College London, London, United Kingdom

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  • Leo C. James mail

    lcj@mrc-lmb.cam.ac.uk

    Affiliation: Medical Research Council Laboratory of Molecular Biology, Division of Protein and Nucleic Acid Chemistry, Cambridge, United Kingdom

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  • Published: August 30, 2012
  • DOI: 10.1371/journal.ppat.1002896

About the Authors

Amanda J. Price, Tom Elliott, Jason W. Chin, Leo C. James
Medical Research Council Laboratory of Molecular Biology, Division of Protein and Nucleic Acid Chemistry, Cambridge, United Kingdom
Adam J. Fletcher, Torsten Schaller, Greg J. Towers
Medical Research Council Centre for Medical Molecular Virology, Division of Infection and Immunity, University College London, London, United Kingdom
KyeongEun Lee, Vineet N. KewalRamani
HIV Drug Resistance Program, National Cancer Institute, Frederick, Maryland, United States of America

Corresponding Author

Email: lcj@mrc-lmb.cam.ac.uk

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: AJP AJF TS GJT LCJ. Performed the experiments: AJP AJF TS TE. Analyzed the data: AJP AJF TS GJT LCJ. Contributed reagents/materials/analysis tools: TE KL VNK JWC. Wrote the paper: AJP AJF VNK GJT LCJ.