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Research Article

Ablation of the Regulatory IE1 Protein of Murine Cytomegalovirus Alters In Vivo Pro-inflammatory TNF-alpha Production during Acute Infection

  • Sara Rodríguez-Martín equal contributor,

    equal contributor Contributed equally to this work with: Sara Rodríguez-Martín, Kai Alexander Kropp

    Affiliation: Division of Pathway Medicine and Centre for Infectious Diseases, University of Edinburgh, Edinburgh, United Kingdom

    X
  • Kai Alexander Kropp equal contributor,

    equal contributor Contributed equally to this work with: Sara Rodríguez-Martín, Kai Alexander Kropp

    Affiliation: Division of Pathway Medicine and Centre for Infectious Diseases, University of Edinburgh, Edinburgh, United Kingdom

    X
  • Vanessa Wilhelmi,

    Affiliation: Institute for Virology, University Medical Center of the Johannes Gutenberg University, Mainz, Germany

    X
  • Vanda Juranic Lisnic,

    Affiliation: Department of Histology and Embryology/Center for Proteomics, Faculty of Medicine, University of Rijeka, Rijeka, Croatia

    X
  • Wei Yuan Hsieh,

    Affiliation: Division of Pathway Medicine and Centre for Infectious Diseases, University of Edinburgh, Edinburgh, United Kingdom

    X
  • Mathieu Blanc,

    Affiliation: Division of Pathway Medicine and Centre for Infectious Diseases, University of Edinburgh, Edinburgh, United Kingdom

    X
  • Andrew Livingston,

    Affiliation: Division of Pathway Medicine and Centre for Infectious Diseases, University of Edinburgh, Edinburgh, United Kingdom

    X
  • Andreas Busche,

    Affiliation: Department of Virology, Hannover Medical School, Hannover, Germany

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  • Hille Tekotte,

    Affiliation: Wellcome Trust Centre for Cell Biology, University of Edinburgh, Edinburgh, United Kingdom

    X
  • Martin Messerle,

    Affiliation: Department of Virology, Hannover Medical School, Hannover, Germany

    X
  • Manfred Auer,

    Affiliation: University of Edinburgh, School of Biological Sciences (CSE) and School of Biomedical Sciences (CMVM), Edinburgh, United Kingdom

    X
  • Iain Fraser,

    Affiliation: Laboratory of Systems Biology, National Institution of Allergy and Infectious Disease, National Institutes of Health, Bethesda, Maryland, United States of America

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  • Stipan Jonjic,

    Affiliation: Department of Histology and Embryology/Center for Proteomics, Faculty of Medicine, University of Rijeka, Rijeka, Croatia

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  • Ana Angulo,

    Affiliation: Institut d'Investigacions Biomediques August Pi i Sunyer, Barcelona, Spain

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  • Matthias J. Reddehase,

    Affiliation: Institute for Virology, University Medical Center of the Johannes Gutenberg University, Mainz, Germany

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  • Peter Ghazal mail

    p.ghazal@ed.ac.uk

    Affiliation: Division of Pathway Medicine and Centre for Infectious Diseases, University of Edinburgh, Edinburgh, United Kingdom

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  • Published: August 30, 2012
  • DOI: 10.1371/journal.ppat.1002901

About the Authors

Sara Rodríguez-Martín, Kai Alexander Kropp, Wei Yuan Hsieh, Mathieu Blanc, Andrew Livingston, Peter Ghazal
Division of Pathway Medicine and Centre for Infectious Diseases, University of Edinburgh, Edinburgh, United Kingdom
Vanessa Wilhelmi, Matthias J. Reddehase
Institute for Virology, University Medical Center of the Johannes Gutenberg University, Mainz, Germany
Vanda Juranic Lisnic, Stipan Jonjic
Department of Histology and Embryology/Center for Proteomics, Faculty of Medicine, University of Rijeka, Rijeka, Croatia
Andreas Busche, Martin Messerle
Department of Virology, Hannover Medical School, Hannover, Germany
Hille Tekotte
Wellcome Trust Centre for Cell Biology, University of Edinburgh, Edinburgh, United Kingdom
Manfred Auer
University of Edinburgh, School of Biological Sciences (CSE) and School of Biomedical Sciences (CMVM), Edinburgh, United Kingdom
Iain Fraser
Laboratory of Systems Biology, National Institution of Allergy and Infectious Disease, National Institutes of Health, Bethesda, Maryland, United States of America
Ana Angulo
Institut d'Investigacions Biomediques August Pi i Sunyer, Barcelona, Spain

Corresponding Author

Email: p.ghazal@ed.ac.uk

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: SRM KAK AL VW VJL MA SJ MJR AA PG. Performed the experiments: SRM KAK WYH AL VW VJL MB HT AB. Analyzed the data: AA MM SJ MJR PG. Contributed reagents/materials/analysis tools: IF. Wrote the paper: SRM KAK VW MJR PG.