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Research Article

Unbiased Mutagenesis of MHV68 LANA Reveals a DNA-Binding Domain Required for LANA Function In Vitro and In Vivo

  • Clinton R. Paden,

    Affiliations: Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, Georgia, United States of America, Immunology and Molecular Pathogenesis Graduate Program, Emory University, Atlanta, Georgia, United States of America

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  • J. Craig Forrest,

    Affiliation: Department of Microbiology and Immunology, University of Arkansas for Medical Sciences, Little Rock, Arkansas, United States of America

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  • Scott A. Tibbetts,

    Affiliation: Department of Molecular Genetics and Microbiology, University of Florida, Gainesville, Florida, United States of America

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  • Samuel H. Speck mail

    sspeck@emory.edu

    Affiliation: Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, Georgia, United States of America

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  • Published: September 06, 2012
  • DOI: 10.1371/journal.ppat.1002906

About the Authors

Clinton R. Paden, Samuel H. Speck
Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, Georgia, United States of America
Clinton R. Paden
Immunology and Molecular Pathogenesis Graduate Program, Emory University, Atlanta, Georgia, United States of America
J. Craig Forrest
Department of Microbiology and Immunology, University of Arkansas for Medical Sciences, Little Rock, Arkansas, United States of America
Scott A. Tibbetts
Department of Molecular Genetics and Microbiology, University of Florida, Gainesville, Florida, United States of America

Corresponding Author

Email: sspeck@emory.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: CRP JCF SHS. Performed the experiments: CRP JCF. Analyzed the data: CRP JCF SHS. Contributed reagents/materials/analysis tools: SAT JCF. Wrote the paper: CRP SHS.