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Research Article

Marburg Virus VP35 Can Both Fully Coat the Backbone and Cap the Ends of dsRNA for Interferon Antagonism

  • Shridhar Bale,

    Affiliation: Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, California, United States of America

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  • Jean-Philippe Julien equal contributor,

    equal contributor Contributed equally to this work with: Jean-Philippe Julien, Zachary A. Bornholdt, Christopher R. Kimberlin

    Affiliation: Department of Molecular Biology, The Scripps Research Institute, La Jolla, California, United States of America

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  • Zachary A. Bornholdt equal contributor,

    equal contributor Contributed equally to this work with: Jean-Philippe Julien, Zachary A. Bornholdt, Christopher R. Kimberlin

    Affiliation: Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, California, United States of America

    X
  • Christopher R. Kimberlin equal contributor,

    equal contributor Contributed equally to this work with: Jean-Philippe Julien, Zachary A. Bornholdt, Christopher R. Kimberlin

    Affiliation: Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, California, United States of America

    Current address: Cardiovascular Research Institute, University of California, San Francisco, San Francisco, California, United States of America.

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  • Peter Halfmann,

    Affiliation: Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin, Madison, Wisconsin, United States of America

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  • Michelle A. Zandonatti,

    Affiliation: Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, California, United States of America

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  • John Kunert,

    Affiliation: Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin, Madison, Wisconsin, United States of America

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  • Gerard J. A. Kroon,

    Affiliation: Department of Molecular Biology, The Scripps Research Institute, La Jolla, California, United States of America

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  • Yoshihiro Kawaoka,

    Affiliations: Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin, Madison, Wisconsin, United States of America, Division of Virology, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, Tokyo, Japan, International Research Center for Infectious Diseases, Institute of Medical Science, University of Tokyo, Tokyo, Japan

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  • Ian J. MacRae,

    Affiliation: Department of Molecular Biology, The Scripps Research Institute, La Jolla, California, United States of America

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  • Ian A. Wilson,

    Affiliations: Department of Molecular Biology, The Scripps Research Institute, La Jolla, California, United States of America, The Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, California, United States of America

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  • Erica Ollmann Saphire mail

    erica@scripps.edu

    Affiliations: Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, California, United States of America, The Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, California, United States of America

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  • Published: September 13, 2012
  • DOI: 10.1371/journal.ppat.1002916

About the Authors

Shridhar Bale, Zachary A. Bornholdt, Christopher R. Kimberlin, Michelle A. Zandonatti, Erica Ollmann Saphire
Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, California, United States of America
Jean-Philippe Julien, Gerard J. A. Kroon, Ian J. MacRae, Ian A. Wilson
Department of Molecular Biology, The Scripps Research Institute, La Jolla, California, United States of America
Peter Halfmann, John Kunert, Yoshihiro Kawaoka
Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin, Madison, Wisconsin, United States of America
Yoshihiro Kawaoka
Division of Virology, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, Tokyo, Japan
Yoshihiro Kawaoka
International Research Center for Infectious Diseases, Institute of Medical Science, University of Tokyo, Tokyo, Japan
Ian A. Wilson, Erica Ollmann Saphire
The Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, California, United States of America

Corresponding Author

Email: erica@scripps.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: SB ZAB CRK JPJ EOS. Performed the experiments: SB CRK JPJ PH JK MAZ GJAK. Analyzed the data: SB ZAB CRK JPJ PH GJAK EOS. Contributed reagents/materials/analysis tools: SB ZAB CRK JPJ PH MAZ JK YK IJM IAW. Wrote the paper: SB ZAB JPJ PH EOS.