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Research Article

Phase Variable O Antigen Biosynthetic Genes Control Expression of the Major Protective Antigen and Bacteriophage Receptor in Vibrio cholerae O1

  • Kimberley D. Seed,

    Affiliation: Howard Hughes Medical Institute and Department of Molecular Biology and Microbiology, Tufts University School of Medicine, Boston, Massachusetts, United States of America

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  • Shah M. Faruque,

    Affiliation: Molecular Genetics Laboratory, International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka, Bangladesh

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  • John J. Mekalanos,

    Affiliation: Department of Microbiology and Molecular Genetics, Harvard Medical School, Boston, Massachusetts, United States of America

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  • Stephen B. Calderwood,

    Affiliation: Division of Infectious Diseases, Massachusetts General Hospital, and Harvard Medical School, Boston, Massachusetts, United States of America

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  • Firdausi Qadri,

    Affiliation: Centre for Vaccine Sciences, International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka, Bangladesh

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  • Andrew Camilli mail

    andrew.camilli@tufts.edu

    Affiliation: Howard Hughes Medical Institute and Department of Molecular Biology and Microbiology, Tufts University School of Medicine, Boston, Massachusetts, United States of America

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  • Published: September 13, 2012
  • DOI: 10.1371/journal.ppat.1002917

About the Authors

Kimberley D. Seed, Andrew Camilli
Howard Hughes Medical Institute and Department of Molecular Biology and Microbiology, Tufts University School of Medicine, Boston, Massachusetts, United States of America
Shah M. Faruque
Molecular Genetics Laboratory, International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka, Bangladesh
John J. Mekalanos
Department of Microbiology and Molecular Genetics, Harvard Medical School, Boston, Massachusetts, United States of America
Stephen B. Calderwood
Division of Infectious Diseases, Massachusetts General Hospital, and Harvard Medical School, Boston, Massachusetts, United States of America
Firdausi Qadri
Centre for Vaccine Sciences, International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka, Bangladesh

Corresponding Author

Email: andrew.camilli@tufts.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: KDS AC. Performed the experiments: KDS AC. Analyzed the data: KDS AC. Contributed reagents/materials/analysis tools: KDS SMF JJM SBC FQ AC. Wrote the paper: KDS AC.