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Research Article

A Cell-Based Screen Reveals that the Albendazole Metabolite, Albendazole Sulfone, Targets Wolbachia

  • Laura R. Serbus equal contributor mail,

    equal contributor Contributed equally to this work with: Laura R. Serbus, Frederic Landmann

    lrserbus@ucsc.edu

    Affiliation: Molecular, Cell and Developmental Biology, University of California, Santa Cruz, California, United States of America

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  • Frederic Landmann equal contributor,

    equal contributor Contributed equally to this work with: Laura R. Serbus, Frederic Landmann

    Affiliation: Molecular, Cell and Developmental Biology, University of California, Santa Cruz, California, United States of America

    X
  • Walter M. Bray,

    Affiliation: Department of Chemistry and Biochemistry, University of California, Santa Cruz, California, United States of America

    X
  • Pamela M. White,

    Affiliation: Molecular, Cell and Developmental Biology, University of California, Santa Cruz, California, United States of America

    X
  • Jordan Ruybal,

    Affiliation: Molecular, Cell and Developmental Biology, University of California, Santa Cruz, California, United States of America

    X
  • R. Scott Lokey,

    Affiliation: Department of Chemistry and Biochemistry, University of California, Santa Cruz, California, United States of America

    X
  • Alain Debec,

    Affiliation: Polarity and Morphogenesis Group, Jacques Monod Institute, CNRS, University Paris Diderot, UPMC Bâtiment Buffon, Paris, France

    X
  • William Sullivan

    Affiliation: Molecular, Cell and Developmental Biology, University of California, Santa Cruz, California, United States of America

    X
  • Published: September 20, 2012
  • DOI: 10.1371/journal.ppat.1002922

About the Authors

Laura R. Serbus, Frederic Landmann, Pamela M. White, Jordan Ruybal, William Sullivan
Molecular, Cell and Developmental Biology, University of California, Santa Cruz, California, United States of America
Walter M. Bray, R. Scott Lokey
Department of Chemistry and Biochemistry, University of California, Santa Cruz, California, United States of America
Alain Debec
Polarity and Morphogenesis Group, Jacques Monod Institute, CNRS, University Paris Diderot, UPMC Bâtiment Buffon, Paris, France

Corresponding Author

Email: lrserbus@ucsc.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: LRS FL WMB JR RSL WS. Performed the experiments: LRS FL WMB PMW JR. Analyzed the data: LRS FL WMB PMW JR WS. Contributed reagents/materials/analysis tools: LRS FL WMB PMW JR RSL AD WS. Wrote the paper: LRS WS. Edited the paper: LRS FL WMB PMW RSL AD WS.