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Research Article

A Novel Rhabdovirus Associated with Acute Hemorrhagic Fever in Central Africa

  • Gilda Grard equal contributor,

    equal contributor Contributed equally to this work with: Gilda Grard, Joseph N. Fair, Deanna Lee

    Affiliations: Viral Emergent Diseases unit, Centre International de Recherches Médicales de Franceville, Franceville, Gabon, MIVEGEC, UMR (IRD 224 - CNRS 5290 - UM1 - UM2), Institut de Recherche pour le Développement, Montpellier, France

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  • Joseph N. Fair equal contributor,

    equal contributor Contributed equally to this work with: Gilda Grard, Joseph N. Fair, Deanna Lee

    Affiliation: Global Viral Forecasting, Incorporated, San Francisco, California, United States of America

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  • Deanna Lee equal contributor,

    equal contributor Contributed equally to this work with: Gilda Grard, Joseph N. Fair, Deanna Lee

    Affiliations: Department of Laboratory Medicine, University of California, San Francisco, California, United States of America, UCSF-Abbott Viral Diagnostics and Discovery Center, San Francisco, California, United States of America

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  • Elizabeth Slikas,

    Affiliation: Blood Systems Research Institute, San Francisco, California, United States of America

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  • Imke Steffen,

    Affiliation: Blood Systems Research Institute, San Francisco, California, United States of America

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  • Jean-Jacques Muyembe,

    Affiliation: Institut National de Recherche Biomédicale, Kinshasa, Democratic Republic of the Congo

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  • Taylor Sittler,

    Affiliations: Department of Laboratory Medicine, University of California, San Francisco, California, United States of America, UCSF-Abbott Viral Diagnostics and Discovery Center, San Francisco, California, United States of America

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  • Narayanan Veeraraghavan,

    Affiliations: Department of Laboratory Medicine, University of California, San Francisco, California, United States of America, UCSF-Abbott Viral Diagnostics and Discovery Center, San Francisco, California, United States of America

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  • J. Graham Ruby,

    Affiliations: Howard Hughes Medical Institute, Chevy Chase, Maryland, United States of America, Department of Biochemistry, University of California, San Francisco, California, United States of America

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  • Chunlin Wang,

    Affiliation: Department of Biochemistry, Stanford University, Stanford, California, United States of America

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  • Maria Makuwa,

    Affiliation: Institut National de Recherche Biomédicale, Kinshasa, Democratic Republic of the Congo

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  • Prime Mulembakani,

    Affiliation: Institut National de Recherche Biomédicale, Kinshasa, Democratic Republic of the Congo

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  • Robert B. Tesh,

    Affiliation: Department of Pathology, University of Texas Medical Branch, Galveston, Texas, United States of America

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  • Jonna Mazet,

    Affiliation: Department of Epidemiology, University of California at Davis, Davis, California, United States of America

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  • Anne W. Rimoin,

    Affiliation: Department of Epidemiology, University of California at Los Angeles, Los Angeles, California, United States of America

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  • Travis Taylor,

    Affiliation: Global Viral Forecasting, Incorporated, San Francisco, California, United States of America

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  • Bradley S. Schneider,

    Affiliation: Global Viral Forecasting, Incorporated, San Francisco, California, United States of America

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  • Graham Simmons,

    Affiliation: Blood Systems Research Institute, San Francisco, California, United States of America

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  • Eric Delwart,

    Affiliation: Blood Systems Research Institute, San Francisco, California, United States of America

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  • Nathan D. Wolfe,

    Affiliation: Global Viral Forecasting, Incorporated, San Francisco, California, United States of America

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  • Charles Y. Chiu mail,

    charles.chiu@ucsf.edu (CYC); eric.leroy@ird.fr (EML)

    Affiliations: Department of Laboratory Medicine, University of California, San Francisco, California, United States of America, UCSF-Abbott Viral Diagnostics and Discovery Center, San Francisco, California, United States of America, Department of Medicine, Division of Infectious Diseases, University of California, San Francisco, San Francisco, California, United States of America

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  • Eric M. Leroy mail

    charles.chiu@ucsf.edu (CYC); eric.leroy@ird.fr (EML)

    Affiliations: Viral Emergent Diseases unit, Centre International de Recherches Médicales de Franceville, Franceville, Gabon, MIVEGEC, UMR (IRD 224 - CNRS 5290 - UM1 - UM2), Institut de Recherche pour le Développement, Montpellier, France

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  • Published: September 27, 2012
  • DOI: 10.1371/journal.ppat.1002924

About the Authors

Gilda Grard, Eric M. Leroy
Viral Emergent Diseases unit, Centre International de Recherches Médicales de Franceville, Franceville, Gabon
Gilda Grard, Eric M. Leroy
MIVEGEC, UMR (IRD 224 - CNRS 5290 - UM1 - UM2), Institut de Recherche pour le Développement, Montpellier, France
Joseph N. Fair, Travis Taylor, Bradley S. Schneider, Nathan D. Wolfe
Global Viral Forecasting, Incorporated, San Francisco, California, United States of America
Deanna Lee, Taylor Sittler, Narayanan Veeraraghavan, Charles Y. Chiu
Department of Laboratory Medicine, University of California, San Francisco, California, United States of America
Deanna Lee, Taylor Sittler, Narayanan Veeraraghavan, Charles Y. Chiu
UCSF-Abbott Viral Diagnostics and Discovery Center, San Francisco, California, United States of America
Elizabeth Slikas, Imke Steffen, Graham Simmons, Eric Delwart
Blood Systems Research Institute, San Francisco, California, United States of America
Jean-Jacques Muyembe, Maria Makuwa, Prime Mulembakani
Institut National de Recherche Biomédicale, Kinshasa, Democratic Republic of the Congo
J. Graham Ruby
Howard Hughes Medical Institute, Chevy Chase, Maryland, United States of America
J. Graham Ruby
Department of Biochemistry, University of California, San Francisco, California, United States of America
Chunlin Wang
Department of Biochemistry, Stanford University, Stanford, California, United States of America
Robert B. Tesh
Department of Pathology, University of Texas Medical Branch, Galveston, Texas, United States of America
Jonna Mazet
Department of Epidemiology, University of California at Davis, Davis, California, United States of America
Anne W. Rimoin
Department of Epidemiology, University of California at Los Angeles, Los Angeles, California, United States of America
Charles Y. Chiu
Department of Medicine, Division of Infectious Diseases, University of California, San Francisco, San Francisco, California, United States of America

Corresponding Authors

Competing Interests

The authors have filed a patent application related to BASV. This does not alter the authors' adherence to all PLOS Pathogens policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: GG JNF DL GS ED NDW CYC EML. Performed the experiments: GG DL ES IS RBT. Analyzed the data: GG JNF DL J-JM NV MM PM GS ED NDW CYC EML. Contributed reagents/materials/analysis tools: TS JGR CW RBT JM AWR TT BSS GS ED NDW CYC EML. Wrote the paper: GG JNF DL IS RBT GS ED NDW CYC EML. Obtained consents from patients and their families: PM.