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Research Article

Structural Basis of Differential Neutralization of DENV-1 Genotypes by an Antibody that Recognizes a Cryptic Epitope

  • S. Kyle Austin,

    Affiliation: Department of Pathology & Immunology, Washington University School of Medicine, Saint Louis, Missouri, United States of America

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  • Kimberly A. Dowd,

    Affiliation: Viral Pathogenesis Section, Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America

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  • Bimmi Shrestha,

    Affiliation: Department of Medicine (Infectious Diseases), Washington University School of Medicine, Saint Louis, Missouri, United States of America

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  • Christopher A. Nelson,

    Affiliation: Department of Pathology & Immunology, Washington University School of Medicine, Saint Louis, Missouri, United States of America

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  • Melissa A. Edeling,

    Affiliation: Department of Pathology & Immunology, Washington University School of Medicine, Saint Louis, Missouri, United States of America

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  • Syd Johnson,

    Affiliation: MacroGenics, Rockville, Maryland, United States of America

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  • Theodore C. Pierson,

    Affiliation: Viral Pathogenesis Section, Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America

    X
  • Michael S. Diamond mail,

    diamond@borcim.wustl.edu (MSD); fremont@wustl.edu (DHF)

    Affiliations: Department of Pathology & Immunology, Washington University School of Medicine, Saint Louis, Missouri, United States of America, Department of Medicine (Infectious Diseases), Washington University School of Medicine, Saint Louis, Missouri, United States of America, Department of Molecular Microbiology, Washington University School of Medicine, Saint Louis, Missouri, United States of America

    X
  • Daved H. Fremont mail

    diamond@borcim.wustl.edu (MSD); fremont@wustl.edu (DHF)

    Affiliations: Department of Pathology & Immunology, Washington University School of Medicine, Saint Louis, Missouri, United States of America, Department of Biochemistry and Molecular Biophysics, Washington University School of Medicine, Saint Louis, Missouri, United States of America

    X
  • Published: October 04, 2012
  • DOI: 10.1371/journal.ppat.1002930

About the Authors

S. Kyle Austin, Christopher A. Nelson, Melissa A. Edeling, Michael S. Diamond, Daved H. Fremont
Department of Pathology & Immunology, Washington University School of Medicine, Saint Louis, Missouri, United States of America
Kimberly A. Dowd, Theodore C. Pierson
Viral Pathogenesis Section, Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
Bimmi Shrestha, Michael S. Diamond
Department of Medicine (Infectious Diseases), Washington University School of Medicine, Saint Louis, Missouri, United States of America
Syd Johnson
MacroGenics, Rockville, Maryland, United States of America
Michael S. Diamond
Department of Molecular Microbiology, Washington University School of Medicine, Saint Louis, Missouri, United States of America
Daved H. Fremont
Department of Biochemistry and Molecular Biophysics, Washington University School of Medicine, Saint Louis, Missouri, United States of America

Corresponding Authors

Competing Interests

MacroGenics has licensed some of the anti-DENV antibodies described in the work from Washington University. Syd Johnson is an employee of MacroGenics. Michael Diamond is a paid consultant of MacroGenics. None of the other authors have financial interests related to this work. This does not alter our adherence to all PLOS Pathogens policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: SKA TCP MSD DHF. Performed the experiments: SKA KAD BS MAE DHF. Analyzed the data: SKA CAN TCP MSD DHF. Contributed reagents/materials/analysis tools: SJ MAE. Wrote the paper: SKA TCP MSD DHF.