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Research Article

DENV Inhibits Type I IFN Production in Infected Cells by Cleaving Human STING

  • Sebastian Aguirre,

    Affiliation: Department of Microbiology and the Global Health and Emerging Pathogens Institute, Mount Sinai School of Medicine, New York City, New York, United States of America

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  • Ana M. Maestre,

    Affiliation: Department of Microbiology and the Global Health and Emerging Pathogens Institute, Mount Sinai School of Medicine, New York City, New York, United States of America

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  • Sarah Pagni,

    Affiliations: Department of Microbiology and the Global Health and Emerging Pathogens Institute, Mount Sinai School of Medicine, New York City, New York, United States of America, Mount Sinai Graduate School of Biological Sciences, Mount Sinai School of Medicine, New York City, New York, United States of America

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  • Jenish R. Patel,

    Affiliations: Department of Microbiology and the Global Health and Emerging Pathogens Institute, Mount Sinai School of Medicine, New York City, New York, United States of America, Mount Sinai Graduate School of Biological Sciences, Mount Sinai School of Medicine, New York City, New York, United States of America

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  • Timothy Savage,

    Affiliation: Department of Microbiology and the Global Health and Emerging Pathogens Institute, Mount Sinai School of Medicine, New York City, New York, United States of America

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  • Delia Gutman,

    Affiliation: Department of Cell Biology, University of Miami School of Medicine, Miami, Florida, United States of America

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  • Kevin Maringer,

    Affiliations: Department of Microbiology and the Global Health and Emerging Pathogens Institute, Mount Sinai School of Medicine, New York City, New York, United States of America, School of Cellular and Molecular Medicine, University of Bristol, Bristol, United Kingdom

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  • Dabeiba Bernal-Rubio,

    Affiliation: Department of Microbiology and the Global Health and Emerging Pathogens Institute, Mount Sinai School of Medicine, New York City, New York, United States of America

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  • Reed S. Shabman,

    Affiliation: Department of Microbiology and the Global Health and Emerging Pathogens Institute, Mount Sinai School of Medicine, New York City, New York, United States of America

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  • Viviana Simon,

    Affiliations: Department of Microbiology and the Global Health and Emerging Pathogens Institute, Mount Sinai School of Medicine, New York City, New York, United States of America, Department of Medicine, Division of Infectious Diseases, Mount Sinai School of Medicine, New York City, New York, United States of America

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  • Juan R. Rodriguez-Madoz,

    Affiliations: Department of Microbiology and the Global Health and Emerging Pathogens Institute, Mount Sinai School of Medicine, New York City, New York, United States of America, Center for Applied Medical Research (CIMA), University of Navarra, Pamplona, Spain

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  • Lubbertus C. F. Mulder,

    Affiliations: Department of Microbiology and the Global Health and Emerging Pathogens Institute, Mount Sinai School of Medicine, New York City, New York, United States of America, Department of Medicine, Division of Infectious Diseases, Mount Sinai School of Medicine, New York City, New York, United States of America

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  • Glen N. Barber,

    Affiliation: Department of Cell Biology, University of Miami School of Medicine, Miami, Florida, United States of America

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  • Ana Fernandez-Sesma mail

    ana.sesma@mssm.edu

    Affiliations: Department of Microbiology and the Global Health and Emerging Pathogens Institute, Mount Sinai School of Medicine, New York City, New York, United States of America, Mount Sinai Graduate School of Biological Sciences, Mount Sinai School of Medicine, New York City, New York, United States of America, Department of Medicine, Division of Infectious Diseases, Mount Sinai School of Medicine, New York City, New York, United States of America

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  • Published: October 04, 2012
  • DOI: 10.1371/journal.ppat.1002934

About the Authors

Sebastian Aguirre, Ana M. Maestre, Sarah Pagni, Jenish R. Patel, Timothy Savage, Kevin Maringer, Dabeiba Bernal-Rubio, Reed S. Shabman, Viviana Simon, Juan R. Rodriguez-Madoz, Lubbertus C. F. Mulder, Ana Fernandez-Sesma
Department of Microbiology and the Global Health and Emerging Pathogens Institute, Mount Sinai School of Medicine, New York City, New York, United States of America
Sarah Pagni, Jenish R. Patel, Ana Fernandez-Sesma
Mount Sinai Graduate School of Biological Sciences, Mount Sinai School of Medicine, New York City, New York, United States of America
Delia Gutman, Glen N. Barber
Department of Cell Biology, University of Miami School of Medicine, Miami, Florida, United States of America
Kevin Maringer
School of Cellular and Molecular Medicine, University of Bristol, Bristol, United Kingdom
Viviana Simon, Lubbertus C. F. Mulder, Ana Fernandez-Sesma
Department of Medicine, Division of Infectious Diseases, Mount Sinai School of Medicine, New York City, New York, United States of America
Juan R. Rodriguez-Madoz
Center for Applied Medical Research (CIMA), University of Navarra, Pamplona, Spain

Corresponding Author

Email: ana.sesma@mssm.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: AFS SA LCFM. Performed the experiments: SA AMM SP JRP TS DBR JRRM LCFM RSS KM. Analyzed the data: SA AMM AFS. Contributed reagents/materials/analysis tools: GNB VS DG. Wrote the paper: SA AFS.