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Research Article

ABO Blood Groups Influence Macrophage-mediated Phagocytosis of Plasmodium falciparum-infected Erythrocytes

  • Kayla T. Wolofsky equal contributor,

    equal contributor Contributed equally to this work with: Kayla T. Wolofsky, Kodjo Ayi

    Affiliations: Sandra Rotman Centre for Global Health, SA Rotman Laboratories, Toronto General Hospital-University Health Network, University of Toronto, Toronto, Ontario, Canada, Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada

    X
  • Kodjo Ayi equal contributor,

    equal contributor Contributed equally to this work with: Kayla T. Wolofsky, Kodjo Ayi

    Affiliation: Sandra Rotman Centre for Global Health, SA Rotman Laboratories, Toronto General Hospital-University Health Network, University of Toronto, Toronto, Ontario, Canada

    X
  • Donald R. Branch,

    Affiliation: Research and Development, Canadian Blood Services, Toronto, Ontario, Canada

    X
  • Annika K. Hult,

    Affiliation: Division of Hematology and Transfusion Medicine, Department of Laboratory Medicine, Lund University, Lund, Sweden

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  • Martin L. Olsson,

    Affiliation: Division of Hematology and Transfusion Medicine, Department of Laboratory Medicine, Lund University, Lund, Sweden

    X
  • W. Conrad Liles,

    Affiliations: Sandra Rotman Centre for Global Health, SA Rotman Laboratories, Toronto General Hospital-University Health Network, University of Toronto, Toronto, Ontario, Canada, Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada, Department of Medicine, University of Washington, Seattle, Washington, United States of America, Tropical Disease Unit, Division of Infectious Diseases, Department of Medicine, Toronto General Hospital-University Health Network, University of Toronto, Toronto, Ontario, Canada

    X
  • Christine M. Cserti-Gazdewich,

    Affiliation: Blood Transfusion Laboratory, Toronto General Hospital-UHN, Toronto, Ontario, Canada

    X
  • Kevin C. Kain mail

    kevin.kain@uhn.ca

    Affiliations: Sandra Rotman Centre for Global Health, SA Rotman Laboratories, Toronto General Hospital-University Health Network, University of Toronto, Toronto, Ontario, Canada, Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada, Tropical Disease Unit, Division of Infectious Diseases, Department of Medicine, Toronto General Hospital-University Health Network, University of Toronto, Toronto, Ontario, Canada

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  • Published: October 11, 2012
  • DOI: 10.1371/journal.ppat.1002942

About the Authors

Kayla T. Wolofsky, Kodjo Ayi, W. Conrad Liles, Kevin C. Kain
Sandra Rotman Centre for Global Health, SA Rotman Laboratories, Toronto General Hospital-University Health Network, University of Toronto, Toronto, Ontario, Canada
Kayla T. Wolofsky, W. Conrad Liles, Kevin C. Kain
Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada
Donald R. Branch
Research and Development, Canadian Blood Services, Toronto, Ontario, Canada
Annika K. Hult, Martin L. Olsson
Division of Hematology and Transfusion Medicine, Department of Laboratory Medicine, Lund University, Lund, Sweden
W. Conrad Liles
Department of Medicine, University of Washington, Seattle, Washington, United States of America
W. Conrad Liles, Kevin C. Kain
Tropical Disease Unit, Division of Infectious Diseases, Department of Medicine, Toronto General Hospital-University Health Network, University of Toronto, Toronto, Ontario, Canada
Christine M. Cserti-Gazdewich
Blood Transfusion Laboratory, Toronto General Hospital-UHN, Toronto, Ontario, Canada

Corresponding Author

Email: kevin.kain@uhn.ca

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: KTW KA DRB WCL MLO CMC KCK. Performed the experiments: KTW KA AKH. Analyzed the data: KTW KA WCL AKH MLO KCK. Contributed reagents/materials/analysis tools: AKH DRB MLO. Wrote the paper: KTW KA KCK. Reviewed and revised the manuscript: KTW KA DRB AKH MLO WCL CMC KCK.