Advertisement
Research Article

A Unique Protein Phosphatase with Kelch-Like Domains (PPKL) in Plasmodium Modulates Ookinete Differentiation, Motility and Invasion

  • David S. Guttery equal contributor,

    equal contributor Contributed equally to this work with: David S. Guttery, Benoit Poulin

    Affiliation: Centre for Genetics and Genomics, School of Biology, Queens Medical Centre, University of Nottingham, Nottingham, United Kingdom

    X
  • Benoit Poulin equal contributor,

    equal contributor Contributed equally to this work with: David S. Guttery, Benoit Poulin

    Affiliation: Centre for Genetics and Genomics, School of Biology, Queens Medical Centre, University of Nottingham, Nottingham, United Kingdom

    X
  • David J. P. Ferguson,

    Affiliation: Nuffield Department of Clinical Laboratory Science, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom

    X
  • Balázs Szöőr,

    Affiliation: Centre for Immunity, Infection and Evolution, Institute of Immunology and Infection Research, School of Biological Sciences, University of Edinburgh, Edinburgh, United Kingdom

    X
  • Bill Wickstead,

    Affiliation: Centre for Genetics and Genomics, School of Biology, Queens Medical Centre, University of Nottingham, Nottingham, United Kingdom

    X
  • Paula L. Carroll,

    Affiliation: Centre for Genetics and Genomics, School of Biology, Queens Medical Centre, University of Nottingham, Nottingham, United Kingdom

    X
  • Chandra Ramakrishnan,

    Affiliation: Division of Cell and Molecular Biology, Imperial College London, London, United Kingdom

    X
  • Declan Brady,

    Affiliation: Centre for Genetics and Genomics, School of Biology, Queens Medical Centre, University of Nottingham, Nottingham, United Kingdom

    X
  • Eva-Maria Patzewitz,

    Affiliation: Centre for Genetics and Genomics, School of Biology, Queens Medical Centre, University of Nottingham, Nottingham, United Kingdom

    X
  • Ursula Straschil,

    Affiliation: Division of Cell and Molecular Biology, Imperial College London, London, United Kingdom

    X
  • Lev Solyakov,

    Affiliation: Medical Research Council Toxicology Unit, Leicester, United Kingdom

    X
  • Judith L. Green,

    Affiliation: Division of Parasitology, MRC National Institute for Medical Research, Mill Hill, London, United Kingdom

    X
  • Robert E. Sinden,

    Affiliation: Division of Cell and Molecular Biology, Imperial College London, London, United Kingdom

    X
  • Andrew B. Tobin,

    Affiliation: Medical Research Council Toxicology Unit, Leicester, United Kingdom

    X
  • Anthony A. Holder,

    Affiliation: Division of Parasitology, MRC National Institute for Medical Research, Mill Hill, London, United Kingdom

    X
  • Rita Tewari mail

    rita.tewari@nottingham.ac.uk

    Affiliation: Centre for Genetics and Genomics, School of Biology, Queens Medical Centre, University of Nottingham, Nottingham, United Kingdom

    X
  • Published: September 20, 2012
  • DOI: 10.1371/journal.ppat.1002948

About the Authors

David S. Guttery, Benoit Poulin, Bill Wickstead, Paula L. Carroll, Declan Brady, Eva-Maria Patzewitz, Rita Tewari
Centre for Genetics and Genomics, School of Biology, Queens Medical Centre, University of Nottingham, Nottingham, United Kingdom
David J. P. Ferguson
Nuffield Department of Clinical Laboratory Science, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom
Balázs Szöőr
Centre for Immunity, Infection and Evolution, Institute of Immunology and Infection Research, School of Biological Sciences, University of Edinburgh, Edinburgh, United Kingdom
Chandra Ramakrishnan, Ursula Straschil, Robert E. Sinden
Division of Cell and Molecular Biology, Imperial College London, London, United Kingdom
Lev Solyakov, Andrew B. Tobin
Medical Research Council Toxicology Unit, Leicester, United Kingdom
Judith L. Green, Anthony A. Holder
Division of Parasitology, MRC National Institute for Medical Research, Mill Hill, London, United Kingdom

Corresponding Author

Email: rita.tewari@nottingham.ac.uk

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: DJPF AAH RT. Performed the experiments: DSG BP DJPF BS BW PLC CR DB EMP US LS RT. Analyzed the data: DSG BP DJPF BS BW PLC CR EMP JLG ABT RES AAH RT. Contributed reagents/materials/analysis tools: DJPF RT. Wrote the paper: DSG BP AAH RT.