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Research Article

De novo GTP Biosynthesis Is Critical for Virulence of the Fungal Pathogen Cryptococcus neoformans

  • Carl A. Morrow,

    Affiliations: Australian Infectious Diseases Research Centre, University of Queensland, Brisbane, Queensland, Australia, School of Chemistry and Molecular Biosciences, University of Queensland, Brisbane, Queensland, Australia

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  • Eugene Valkov,

    Affiliations: School of Chemistry and Molecular Biosciences, University of Queensland, Brisbane, Queensland, Australia, MRC Laboratory of Molecular Biology, Cambridge, United Kingdom, Division of Chemistry and Structural Biology, Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland, Australia

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  • Anna Stamp,

    Affiliation: School of Chemistry and Molecular Biosciences, University of Queensland, Brisbane, Queensland, Australia

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  • Eve W. L. Chow,

    Affiliations: Australian Infectious Diseases Research Centre, University of Queensland, Brisbane, Queensland, Australia, School of Chemistry and Molecular Biosciences, University of Queensland, Brisbane, Queensland, Australia

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  • I. Russel Lee,

    Affiliations: Australian Infectious Diseases Research Centre, University of Queensland, Brisbane, Queensland, Australia, School of Chemistry and Molecular Biosciences, University of Queensland, Brisbane, Queensland, Australia

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  • Ania Wronski,

    Affiliation: School of Chemistry and Molecular Biosciences, University of Queensland, Brisbane, Queensland, Australia

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  • Simon J. Williams,

    Affiliations: Australian Infectious Diseases Research Centre, University of Queensland, Brisbane, Queensland, Australia, School of Chemistry and Molecular Biosciences, University of Queensland, Brisbane, Queensland, Australia

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  • Justine M. Hill,

    Affiliations: School of Chemistry and Molecular Biosciences, University of Queensland, Brisbane, Queensland, Australia, Centre for Advanced Imaging, University of Queensland, Brisbane, Queensland, Australia

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  • Julianne T. Djordjevic,

    Affiliation: Centre for Infectious Diseases and Microbiology, Westmead Millennium Institute, University of Sydney at Westmead Hospital, Sydney, New South Wales, Australia

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  • Ulrike Kappler,

    Affiliations: Australian Infectious Diseases Research Centre, University of Queensland, Brisbane, Queensland, Australia, School of Chemistry and Molecular Biosciences, University of Queensland, Brisbane, Queensland, Australia

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  • Bostjan Kobe,

    Affiliations: Australian Infectious Diseases Research Centre, University of Queensland, Brisbane, Queensland, Australia, School of Chemistry and Molecular Biosciences, University of Queensland, Brisbane, Queensland, Australia, Division of Chemistry and Structural Biology, Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland, Australia

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  • James A. Fraser mail

    jafraser@uq.edu.au

    Affiliations: Australian Infectious Diseases Research Centre, University of Queensland, Brisbane, Queensland, Australia, School of Chemistry and Molecular Biosciences, University of Queensland, Brisbane, Queensland, Australia

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  • Published: October 11, 2012
  • DOI: 10.1371/journal.ppat.1002957

About the Authors

Carl A. Morrow, Eve W. L. Chow, I. Russel Lee, Simon J. Williams, Ulrike Kappler, Bostjan Kobe, James A. Fraser
Australian Infectious Diseases Research Centre, University of Queensland, Brisbane, Queensland, Australia
Carl A. Morrow, Eugene Valkov, Anna Stamp, Eve W. L. Chow, I. Russel Lee, Ania Wronski, Simon J. Williams, Justine M. Hill, Ulrike Kappler, Bostjan Kobe, James A. Fraser
School of Chemistry and Molecular Biosciences, University of Queensland, Brisbane, Queensland, Australia
Eugene Valkov
MRC Laboratory of Molecular Biology, Cambridge, United Kingdom
Eugene Valkov, Bostjan Kobe
Division of Chemistry and Structural Biology, Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland, Australia
Justine M. Hill
Centre for Advanced Imaging, University of Queensland, Brisbane, Queensland, Australia
Julianne T. Djordjevic
Centre for Infectious Diseases and Microbiology, Westmead Millennium Institute, University of Sydney at Westmead Hospital, Sydney, New South Wales, Australia

Corresponding Author

Email: jafraser@uq.edu.au

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: CAM UK BK JAF. Performed the experiments: CAM EV AS EWLC IRL AW SJW JMH JTD. Analyzed the data: CAM EV JAF. Wrote the paper: CAM JAF.