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Research Article

Humanized TLR4/MD-2 Mice Reveal LPS Recognition Differentially Impacts Susceptibility to Yersinia pestis and Salmonella enterica

  • Adeline M. Hajjar mail,

    hajjar@uw.edu

    Affiliation: Department of Comparative Medicine, University of Washington, Seattle, Washington, United States of America

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  • Robert K. Ernst equal contributor,

    equal contributor Contributed equally to this work with: Robert K. Ernst, Edgardo S. Fortuno III

    Affiliation: Department of Microbial Pathogenesis, University of Maryland, Baltimore, Maryland, United States of America

    X
  • Edgardo S. Fortuno III equal contributor,

    equal contributor Contributed equally to this work with: Robert K. Ernst, Edgardo S. Fortuno III

    Affiliation: Division of Infectious and Immunological Diseases, University of British Columbia, Vancouver, British Columbia, Canada

    X
  • Alicia S. Brasfield,

    Affiliation: Department of Comparative Medicine, University of Washington, Seattle, Washington, United States of America

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  • Cathy S. Yam,

    Affiliation: Department of Comparative Medicine, University of Washington, Seattle, Washington, United States of America

    X
  • Lindsay A. Newlon,

    Affiliation: Department of Immunology, University of Washington, Seattle, Washington, United States of America

    X
  • Tobias R. Kollmann,

    Affiliation: Division of Infectious and Immunological Diseases, University of British Columbia, Vancouver, British Columbia, Canada

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  • Samuel I. Miller,

    Affiliation: Departments of Medicine, Genome Sciences, and Microbiology, University of Washington, Seattle, Washington, United States of America

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  • Christopher B. Wilson

    Affiliation: Department of Immunology, University of Washington, Seattle, Washington, United States of America

    Current address: Bill & Melinda Gates Foundation, Seattle, Washington, United States of America

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  • Published: October 11, 2012
  • DOI: 10.1371/journal.ppat.1002963

About the Authors

Adeline M. Hajjar, Alicia S. Brasfield, Cathy S. Yam
Department of Comparative Medicine, University of Washington, Seattle, Washington, United States of America
Robert K. Ernst
Department of Microbial Pathogenesis, University of Maryland, Baltimore, Maryland, United States of America
Edgardo S. Fortuno III, Tobias R. Kollmann
Division of Infectious and Immunological Diseases, University of British Columbia, Vancouver, British Columbia, Canada
Lindsay A. Newlon, Christopher B. Wilson
Department of Immunology, University of Washington, Seattle, Washington, United States of America
Samuel I. Miller
Departments of Medicine, Genome Sciences, and Microbiology, University of Washington, Seattle, Washington, United States of America

Corresponding Author

Email: hajjar@uw.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: AMH RKE ESF TRK SIM CBW. Performed the experiments: AMH ESF RKE ASB CSY LAN. Analyzed the data: AMH RKE ESF ASB CSY LAN TRK SIM CBW. Contributed reagents/materials/analysis tools: AMH RKE ESF TRK. Wrote the paper: AMH RKE ESF ASB CSY LAN TRK SIM CBW.