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Research Article

Scavenger Receptor Class A Plays a Central Role in Mediating Mortality and the Development of the Pro-Inflammatory Phenotype in Polymicrobial Sepsis

  • Tammy R. Ozment mail,

    ozmentsk@etsu.edu

    Affiliation: Department of Surgery, East Tennessee State University, Quillen College of Medicine, Johnson City, Tennessee, United States of America

    X
  • Tuanzhu Ha,

    Affiliation: Department of Surgery, East Tennessee State University, Quillen College of Medicine, Johnson City, Tennessee, United States of America

    X
  • Kevin F. Breuel,

    Affiliation: Department of Obstetrics and Gynecology, East Tennessee State University, Quillen College of Medicine, Johnson City, Tennessee, United States of America

    X
  • Tiffany R. Ford,

    Affiliation: Department of Obstetrics and Gynecology, East Tennessee State University, Quillen College of Medicine, Johnson City, Tennessee, United States of America

    X
  • Donald A. Ferguson,

    Affiliation: Department of Biomedical Sciences, East Tennessee State University, Quillen College of Medicine, Johnson City, Tennessee, United States of America

    X
  • John Kalbfleisch,

    Affiliation: Department of Medical Education, East Tennessee State University, Quillen College of Medicine, Johnson City, Tennessee, United States of America

    X
  • John B. Schweitzer,

    Affiliation: Department of Pathology, East Tennessee State University, Quillen College of Medicine, Johnson City, Tennessee, United States of America

    X
  • Jim L. Kelley,

    Affiliation: Department of Internal Medicine, East Tennessee State University, Quillen College of Medicine, Johnson City, Tennessee, United States of America

    X
  • Chuanfu Li,

    Affiliation: Department of Surgery, East Tennessee State University, Quillen College of Medicine, Johnson City, Tennessee, United States of America

    X
  • David L. Williams

    Affiliation: Department of Surgery, East Tennessee State University, Quillen College of Medicine, Johnson City, Tennessee, United States of America

    X
  • Published: October 11, 2012
  • DOI: 10.1371/journal.ppat.1002967

About the Authors

Tammy R. Ozment, Tuanzhu Ha, Chuanfu Li, David L. Williams
Department of Surgery, East Tennessee State University, Quillen College of Medicine, Johnson City, Tennessee, United States of America
Kevin F. Breuel, Tiffany R. Ford
Department of Obstetrics and Gynecology, East Tennessee State University, Quillen College of Medicine, Johnson City, Tennessee, United States of America
Donald A. Ferguson
Department of Biomedical Sciences, East Tennessee State University, Quillen College of Medicine, Johnson City, Tennessee, United States of America
John Kalbfleisch
Department of Medical Education, East Tennessee State University, Quillen College of Medicine, Johnson City, Tennessee, United States of America
John B. Schweitzer
Department of Pathology, East Tennessee State University, Quillen College of Medicine, Johnson City, Tennessee, United States of America
Jim L. Kelley
Department of Internal Medicine, East Tennessee State University, Quillen College of Medicine, Johnson City, Tennessee, United States of America

Corresponding Author

Email: ozmentsk@etsu.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: TRO TH JLK CL DLW. Performed the experiments: TRO TH KFB TRF DAF JBS. Analyzed the data: TRO JBS JK. Contributed reagents/materials/analysis tools: KFB. Wrote the paper: TRO TH DLW.