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Research Article

Rhinovirus Attenuates Non-typeable Hemophilus influenzae-stimulated IL-8 Responses via TLR2-dependent Degradation of IRAK-1

  • Benjamin L. Unger equal contributor,

    equal contributor Contributed equally to this work with: Benjamin L. Unger, Andrea N. Faris

    Affiliation: Department of Pediatrics and Communicable Diseases, University of Michigan, Ann Arbor, Michigan, United States of America

    X
  • Andrea N. Faris equal contributor,

    equal contributor Contributed equally to this work with: Benjamin L. Unger, Andrea N. Faris

    Affiliation: Department of Pediatrics and Communicable Diseases, University of Michigan, Ann Arbor, Michigan, United States of America

    X
  • Shyamala Ganesan,

    Affiliation: Department of Pediatrics and Communicable Diseases, University of Michigan, Ann Arbor, Michigan, United States of America

    X
  • Adam T. Comstock,

    Affiliation: Department of Pediatrics and Communicable Diseases, University of Michigan, Ann Arbor, Michigan, United States of America

    X
  • Marc B. Hershenson,

    Affiliations: Department of Pediatrics and Communicable Diseases, University of Michigan, Ann Arbor, Michigan, United States of America, Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, Michigan, United States of America

    X
  • Umadevi S. Sajjan mail

    usajjan@umich.edu

    Affiliation: Department of Pediatrics and Communicable Diseases, University of Michigan, Ann Arbor, Michigan, United States of America

    X
  • Published: October 04, 2012
  • DOI: 10.1371/journal.ppat.1002969

About the Authors

Benjamin L. Unger, Andrea N. Faris, Shyamala Ganesan, Adam T. Comstock, Marc B. Hershenson, Umadevi S. Sajjan
Department of Pediatrics and Communicable Diseases, University of Michigan, Ann Arbor, Michigan, United States of America
Marc B. Hershenson
Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, Michigan, United States of America

Corresponding Author

Email: usajjan@umich.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: BLU ANF USS. Performed the experiments: BLU ANF SG ATC. Analyzed the data: BLU ANF SG USS. Contributed reagents/materials/analysis tools: USS. Wrote the paper: BLU MBH USS.