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Research Article

Niclosamide Is a Proton Carrier and Targets Acidic Endosomes with Broad Antiviral Effects

  • Andreas Jurgeit,

    Affiliation: Institute of Molecular Life Sciences, University of Zurich, Zurich, Switzerland

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  • Robert McDowell,

    Affiliation: 3-V Biosciences Inc., Menlo Park, California, United States of America

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  • Stefan Moese,

    Affiliation: 3-V Biosciences Inc., Menlo Park, California, United States of America

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  • Eric Meldrum,

    Affiliation: 3-V Biosciences Inc., Menlo Park, California, United States of America

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  • Reto Schwendener,

    Affiliation: Institute of Molecular Cancer Research, University of Zurich, Zurich, Switzerland

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  • Urs F. Greber mail

    urs.greber@imls.uzh.ch

    Affiliation: Institute of Molecular Life Sciences, University of Zurich, Zurich, Switzerland

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  • Published: October 25, 2012
  • DOI: 10.1371/journal.ppat.1002976

About the Authors

Andreas Jurgeit, Urs F. Greber
Institute of Molecular Life Sciences, University of Zurich, Zurich, Switzerland
Robert McDowell, Stefan Moese, Eric Meldrum
3-V Biosciences Inc., Menlo Park, California, United States of America
Reto Schwendener
Institute of Molecular Cancer Research, University of Zurich, Zurich, Switzerland

Corresponding Author

Email: urs.greber@imls.uzh.ch

Competing Interests

I have read the journal's policy and have the following conflicts: 3-V Biosciences is a commercial organization developing antiviral agents. 3-V Biosciences provided support for part of the research but had no decision on how to perform or publish the research. This does not alter our adherence to all PLoS Pathogens policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: AJ EM UFG. Performed the experiments: AJ. Analyzed the data: AJ UFG. Contributed reagents/materials/analysis tools: RM SM RS. Wrote the paper: AJ UFG. AJ, EM and UFG initiated the study. UFG coordinated the study.