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Research Article

The Genome of the Obligate Intracellular Parasite Trachipleistophora hominis: New Insights into Microsporidian Genome Dynamics and Reductive Evolution

  • Eva Heinz,

    Affiliation: Institute for Cell and Molecular Biosciences, The Medical School, Newcastle University, Newcastle upon Tyne, United Kingdom

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  • Tom A. Williams,

    Affiliation: Institute for Cell and Molecular Biosciences, The Medical School, Newcastle University, Newcastle upon Tyne, United Kingdom

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  • Sirintra Nakjang,

    Affiliation: Institute for Cell and Molecular Biosciences, The Medical School, Newcastle University, Newcastle upon Tyne, United Kingdom

    X
  • Christophe J. Noël,

    Affiliation: Institute for Cell and Molecular Biosciences, The Medical School, Newcastle University, Newcastle upon Tyne, United Kingdom

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  • Daniel C. Swan,

    Affiliation: Institute for Cell and Molecular Biosciences, The Medical School, Newcastle University, Newcastle upon Tyne, United Kingdom

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  • Alina V. Goldberg,

    Affiliation: Institute for Cell and Molecular Biosciences, The Medical School, Newcastle University, Newcastle upon Tyne, United Kingdom

    X
  • Simon R. Harris,

    Affiliation: Institute for Cell and Molecular Biosciences, The Medical School, Newcastle University, Newcastle upon Tyne, United Kingdom

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  • Thomas Weinmaier,

    Affiliation: Department of Computational Systems Biology, University of Vienna, Vienna, Austria

    X
  • Stephanie Markert,

    Affiliation: Institute of Pharmacy, Ernst-Moritz-Arndt-University Greifswald, Greifswald, Germany

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  • Dörte Becher,

    Affiliation: Institute of Microbiology, Ernst-Moritz-Arndt-University Greifswald, Greifswald, Germany

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  • Jörg Bernhardt,

    Affiliation: Institute of Microbiology, Ernst-Moritz-Arndt-University Greifswald, Greifswald, Germany

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  • Tal Dagan,

    Affiliation: Institute for Molecular Evolution, Heinrich Heine University Düsseldorf, Düsseldorf, Germany

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  • Christian Hacker,

    Affiliation: School of Medicine, University of St Andrews, St Andrews, Scotland

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  • John M. Lucocq,

    Affiliation: School of Medicine, University of St Andrews, St Andrews, Scotland

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  • Thomas Schweder,

    Affiliation: Institute of Pharmacy, Ernst-Moritz-Arndt-University Greifswald, Greifswald, Germany

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  • Thomas Rattei,

    Affiliation: Department of Computational Systems Biology, University of Vienna, Vienna, Austria

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  • Neil Hall,

    Affiliation: Department of Functional and Comparative Genomics, School of Biological Sciences, University of Liverpool, Liverpool, United Kingdom

    X
  • Robert P. Hirt mail,

    robert.hirt@newcastle.ac.uk (RPH); Martin.Embley@ncl.ac.uk (TME)

    Affiliation: Institute for Cell and Molecular Biosciences, The Medical School, Newcastle University, Newcastle upon Tyne, United Kingdom

    X
  • T. Martin Embley mail

    robert.hirt@newcastle.ac.uk (RPH); Martin.Embley@ncl.ac.uk (TME)

    Affiliation: Institute for Cell and Molecular Biosciences, The Medical School, Newcastle University, Newcastle upon Tyne, United Kingdom

    X
  • Published: October 25, 2012
  • DOI: 10.1371/journal.ppat.1002979

About the Authors

Eva Heinz, Tom A. Williams, Sirintra Nakjang, Christophe J. Noël, Daniel C. Swan, Alina V. Goldberg, Simon R. Harris, Robert P. Hirt, T. Martin Embley
Institute for Cell and Molecular Biosciences, The Medical School, Newcastle University, Newcastle upon Tyne, United Kingdom
Thomas Weinmaier, Thomas Rattei
Department of Computational Systems Biology, University of Vienna, Vienna, Austria
Stephanie Markert, Thomas Schweder
Institute of Pharmacy, Ernst-Moritz-Arndt-University Greifswald, Greifswald, Germany
Dörte Becher, Jörg Bernhardt
Institute of Microbiology, Ernst-Moritz-Arndt-University Greifswald, Greifswald, Germany
Tal Dagan
Institute for Molecular Evolution, Heinrich Heine University Düsseldorf, Düsseldorf, Germany
Christian Hacker, John M. Lucocq
School of Medicine, University of St Andrews, St Andrews, Scotland
Neil Hall
Department of Functional and Comparative Genomics, School of Biological Sciences, University of Liverpool, Liverpool, United Kingdom

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: TME RPH EH TAW SN SM CH JML TS TR NH. Performed the experiments: EH CJN AVG SM DB CH NH. Analyzed the data: EH TAW SN DCS SRH TW SM JB TD CH JML TS TR RPH TME. Contributed reagents/materials/analysis tools: CJN AVG EH. Wrote the paper: EH TAW SN SM TD CH JML RPH TME.