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Research Article

Brucella β 1,2 Cyclic Glucan Is an Activator of Human and Mouse Dendritic Cells

  • Anna Martirosyan,

    Affiliations: Centre d'Immunologie de Marseille-Luminy (CIML), Aix-Marseille University, UM2, Marseille, France, Institut National de la Santé et de la Recherche Médicale (INSERM), U1104, Marseille, France, Centre National de la Recherche Scientifique (CNRS), UMR7280, Marseille, France

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  • Camino Pérez-Gutierrez,

    Affiliation: Fundación Investigación Sanitaria Illes Balears-CSIC, Bunyola, Spain

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  • Romain Banchereau,

    Affiliation: Baylor Institute for Immunology Research and INSERM U899, Dallas, Texas, United States of America

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  • Hélène Dutartre,

    Affiliation: Baylor Institute for Immunology Research and INSERM U899, Dallas, Texas, United States of America

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  • Patrick Lecine,

    Affiliation: Baylor Institute for Immunology Research and INSERM U899, Dallas, Texas, United States of America

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  • Melissa Dullaers,

    Affiliation: Laboratory of Immunoregulation and Mucosal Immunity, Department of Pneumology, Gent, Belgium

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  • Marielle Mello,

    Affiliations: Centre d'Immunologie de Marseille-Luminy (CIML), Aix-Marseille University, UM2, Marseille, France, Institut National de la Santé et de la Recherche Médicale (INSERM), U1104, Marseille, France, Centre National de la Recherche Scientifique (CNRS), UMR7280, Marseille, France

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  • Suzana Pinto Salcedo,

    Affiliations: Centre d'Immunologie de Marseille-Luminy (CIML), Aix-Marseille University, UM2, Marseille, France, Institut National de la Santé et de la Recherche Médicale (INSERM), U1104, Marseille, France, Centre National de la Recherche Scientifique (CNRS), UMR7280, Marseille, France

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  • Alexandre Muller,

    Affiliations: Centre d'Immunologie de Marseille-Luminy (CIML), Aix-Marseille University, UM2, Marseille, France, Institut National de la Santé et de la Recherche Médicale (INSERM), U1104, Marseille, France, Centre National de la Recherche Scientifique (CNRS), UMR7280, Marseille, France

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  • Lee Leserman,

    Affiliations: Centre d'Immunologie de Marseille-Luminy (CIML), Aix-Marseille University, UM2, Marseille, France, Institut National de la Santé et de la Recherche Médicale (INSERM), U1104, Marseille, France, Centre National de la Recherche Scientifique (CNRS), UMR7280, Marseille, France

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  • Yves Levy,

    Affiliations: IINSERM U955 Equipe 16, Institut Mondor de Recherche Biomédicale, Créteil, France, Université Paris-Est, Faculté de Médecine, UMR-S 955 Créteil, France, Assistance Publique-Hôpitaux de Paris (AP-HP), Groupe Henri-Mondor Albert-Chenevier, 9 service d'immunologie clinique, Créteil, France

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  • Gerard Zurawski,

    Affiliation: Baylor Institute for Immunology Research and INSERM U899, Dallas, Texas, United States of America

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  • Sandy Zurawski,

    Affiliation: Baylor Institute for Immunology Research and INSERM U899, Dallas, Texas, United States of America

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  • Edgardo Moreno,

    Affiliations: Programa de Investigación en Enfermedades Tropicales, Escuela de Medicina Veterinaria, Universidad Nacional, Heredia, Costa Rica, Centro de Investigación en Enfermedades Tropicales, Universidad de Costa Rica, San José, Costa Rica, Instituto Clodomiro Picado, Universidad de Costa Rica, San José, Costa Rica

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  • Ignacio Moriyón,

    Affiliation: Institute for Tropical Health and Departamento de Microbiología y Parasitología, Universidad de Navarra, Pamplona, Spain

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  • Eynav Klechevsky,

    Affiliations: Baylor Institute for Immunology Research and INSERM U899, Dallas, Texas, United States of America, Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri, United States of America

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  • Jacques Banchereau,

    Affiliations: Baylor Institute for Immunology Research and INSERM U899, Dallas, Texas, United States of America, Pharma Research and Early Development, Hoffmann-La Roche, Nutley, New Jersey, United States of America

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  • SangKon Oh,

    Affiliation: Baylor Institute for Immunology Research and INSERM U899, Dallas, Texas, United States of America

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  • Jean-Pierre Gorvel mail

    gorvel@ciml.univ-mrs.fr

    Affiliations: Centre d'Immunologie de Marseille-Luminy (CIML), Aix-Marseille University, UM2, Marseille, France, Institut National de la Santé et de la Recherche Médicale (INSERM), U1104, Marseille, France, Centre National de la Recherche Scientifique (CNRS), UMR7280, Marseille, France

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  • Published: November 15, 2012
  • DOI: 10.1371/journal.ppat.1002983

About the Authors

Anna Martirosyan, Marielle Mello, Suzana Pinto Salcedo, Alexandre Muller, Lee Leserman, Jean-Pierre Gorvel
Centre d'Immunologie de Marseille-Luminy (CIML), Aix-Marseille University, UM2, Marseille, France
Anna Martirosyan, Marielle Mello, Suzana Pinto Salcedo, Alexandre Muller, Lee Leserman, Jean-Pierre Gorvel
Institut National de la Santé et de la Recherche Médicale (INSERM), U1104, Marseille, France
Anna Martirosyan, Marielle Mello, Suzana Pinto Salcedo, Alexandre Muller, Lee Leserman, Jean-Pierre Gorvel
Centre National de la Recherche Scientifique (CNRS), UMR7280, Marseille, France
Camino Pérez-Gutierrez
Fundación Investigación Sanitaria Illes Balears-CSIC, Bunyola, Spain
Romain Banchereau, Hélène Dutartre, Patrick Lecine, Gerard Zurawski, Sandy Zurawski, Eynav Klechevsky, Jacques Banchereau, SangKon Oh
Baylor Institute for Immunology Research and INSERM U899, Dallas, Texas, United States of America
Melissa Dullaers
Laboratory of Immunoregulation and Mucosal Immunity, Department of Pneumology, Gent, Belgium
Yves Levy
IINSERM U955 Equipe 16, Institut Mondor de Recherche Biomédicale, Créteil, France
Yves Levy
Université Paris-Est, Faculté de Médecine, UMR-S 955 Créteil, France
Yves Levy
Assistance Publique-Hôpitaux de Paris (AP-HP), Groupe Henri-Mondor Albert-Chenevier, 9 service d'immunologie clinique, Créteil, France
Edgardo Moreno
Programa de Investigación en Enfermedades Tropicales, Escuela de Medicina Veterinaria, Universidad Nacional, Heredia, Costa Rica
Edgardo Moreno
Centro de Investigación en Enfermedades Tropicales, Universidad de Costa Rica, San José, Costa Rica
Edgardo Moreno
Instituto Clodomiro Picado, Universidad de Costa Rica, San José, Costa Rica
Ignacio Moriyón
Institute for Tropical Health and Departamento de Microbiología y Parasitología, Universidad de Navarra, Pamplona, Spain
Eynav Klechevsky
Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri, United States of America
Jacques Banchereau
Pharma Research and Early Development, Hoffmann-La Roche, Nutley, New Jersey, United States of America

Corresponding Author

Email: gorvel@ciml.univ-mrs.fr

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: A. Martirosyan, R. Banchereau, H. Dutartre, P. Lecine, S. Pinto Salcedo, L. Leserman, Y. Levy, G. Zurawski, S. Zurawski, E. Moreno, E. Klechevsky, J. Banchereau, S. Oh, J.-P. Gorvel. Performed the experiments: A. Martirosyan, C. Pérez-Gutierrez, R. Banchereau, H. Dutartre, P. Lecine, M. Dullaers, M. Mello, A. Muller, S. Zurawski, E. Klechevsky, S. Oh. Analyzed the data: A. Martirosyan, C. Pérez-Gutierrez, R. Banchereau, H. Dutartre, P. Lecine, L. Leserman, S. Pinto Salcedo, E. Moreno, I. Moriyón, G. Zurawski, E. Klechevsky, J. Banchereau, S. Oh, J.-P. Gorvel. Contributed reagents/materials/analysis tools: L. Leserman, E. Moreno, I. Moriyón, E. Klechevsky, J. Banchereau, S. Oh, J.-P. Gorvel. Wrote the paper: A. Martirosyan, R. Banchereau, H. Dutartre, P. Lecine, L. Leserman, E. Moreno, I. Moriyón, J. Banchereau, S. Oh, J.-P. Gorvel. Perfomed ex vivo experiments in mice: A. Martirosyan, C. Pérez-Gutierrez. Performed in vivo experiments in mice: A. Martirosyan, M. Mello, E. Moreno. Performed human ex vivo experiments: A. Martirosyan, C. Pérez-Gutierrez, M. Dullaers, S. Oh, E. Klechevsky, R. Banchereau, H. Dutartre, P. Lecine, S. Zurawski. Performed ex vivo infections: A. Muller, S. Pinto Salcedo. Obtained permission for mouse studies: J-P. Gorvel, I. Moriyón, E. Moreno. Obtained permission for human studies: J. Banchereau, S. Oh, H. Dutartre, P. Lecine.