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Research Article

Myeloid-Related Protein-14 Contributes to Protective Immunity in Gram-Negative Pneumonia Derived Sepsis

  • Ahmed Achouiti mail,

    a.achouiti@amc.nl

    Affiliations: Center for Experimental and Molecular Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands, Center for Infection and Immunity, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands

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  • Thomas Vogl,

    Affiliation: Institute of Immunology, University of Münster, Münster, Germany

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  • Constantin F. Urban,

    Affiliation: Clinical Microbiology Department, Laboratory for Molecular Infection Medicine Sweden, Umeå University, Umeå, Sweden

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  • Marc Röhm,

    Affiliation: Clinical Microbiology Department, Laboratory for Molecular Infection Medicine Sweden, Umeå University, Umeå, Sweden

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  • Tijmen J. Hommes,

    Affiliations: Center for Experimental and Molecular Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands, Center for Infection and Immunity, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands

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  • Marieke A. D. van Zoelen,

    Affiliations: Center for Experimental and Molecular Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands, Center for Infection and Immunity, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands

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  • Sandrine Florquin,

    Affiliation: Department of Pathology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands

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  • Johannes Roth,

    Affiliation: Institute of Immunology, University of Münster, Münster, Germany

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  • Cornelis van 't Veer,

    Affiliations: Center for Experimental and Molecular Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands, Center for Infection and Immunity, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands

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  • Alex F. de Vos,

    Affiliations: Center for Experimental and Molecular Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands, Center for Infection and Immunity, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands

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  • Tom van der Poll

    Affiliations: Center for Experimental and Molecular Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands, Center for Infection and Immunity, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands, Division of Infectious Diseases, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands

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  • Published: October 25, 2012
  • DOI: 10.1371/journal.ppat.1002987

About the Authors

Ahmed Achouiti, Tijmen J. Hommes, Marieke A. D. van Zoelen, Cornelis van 't Veer, Alex F. de Vos, Tom van der Poll
Center for Experimental and Molecular Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
Ahmed Achouiti, Tijmen J. Hommes, Marieke A. D. van Zoelen, Cornelis van 't Veer, Alex F. de Vos, Tom van der Poll
Center for Infection and Immunity, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
Thomas Vogl, Johannes Roth
Institute of Immunology, University of Münster, Münster, Germany
Constantin F. Urban, Marc Röhm
Clinical Microbiology Department, Laboratory for Molecular Infection Medicine Sweden, Umeå University, Umeå, Sweden
Sandrine Florquin
Department of Pathology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
Tom van der Poll
Division of Infectious Diseases, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands

Corresponding Author

Email: a.achouiti@amc.nl

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: AA CvV AFdV TvdP. Performed the experiments: AA TV CFU MR TJH. Analyzed the data: AA CFU MADvZ JR CvV AFdV TvdP. Contributed reagents/materials/analysis tools: TV JR. Wrote the paper: AA TvdP. Performed pathology analyses: SF.