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Research Article

Chitinase Dependent Control of Protozoan Cyst Burden in the Brain

  • J. Philip Nance,

    Affiliation: Division of Biomedical Sciences, University of California, Riverside, California, United States of America

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  • Kevin M. Vannella,

    Affiliation: National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America

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  • Danielle Worth,

    Affiliation: Division of Biomedical Sciences, University of California, Riverside, California, United States of America

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  • Clément David,

    Affiliation: Division of Biomedical Sciences, University of California, Riverside, California, United States of America

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  • David Carter,

    Affiliation: Institute for Integrative Genome Biology, University of California, Riverside, California, United States of America

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  • Shahani Noor,

    Affiliation: Division of Biomedical Sciences, University of California, Riverside, California, United States of America

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  • Cedric Hubeau,

    Affiliation: Department of Inflammation and Immunology, Pfizer, Cambridge, Massachusetts, United States of America

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  • Lori Fitz,

    Affiliation: Department of Inflammation and Immunology, Pfizer, Cambridge, Massachusetts, United States of America

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  • Thomas E. Lane,

    Affiliation: Department of Molecular Biology and Biochemistry, Institute for Immunology, University of California, Irvine, Irvine, California, United States of America

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  • Thomas A. Wynn,

    Affiliation: National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America

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  • Emma H. Wilson mail

    emmaw@ucr.edu

    Affiliation: Division of Biomedical Sciences, University of California, Riverside, California, United States of America

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  • Published: November 29, 2012
  • DOI: 10.1371/journal.ppat.1002990

About the Authors

J. Philip Nance, Danielle Worth, Clément David, Shahani Noor, Emma H. Wilson
Division of Biomedical Sciences, University of California, Riverside, California, United States of America
Kevin M. Vannella, Thomas A. Wynn
National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
David Carter
Institute for Integrative Genome Biology, University of California, Riverside, California, United States of America
Cedric Hubeau, Lori Fitz
Department of Inflammation and Immunology, Pfizer, Cambridge, Massachusetts, United States of America
Thomas E. Lane
Department of Molecular Biology and Biochemistry, Institute for Immunology, University of California, Irvine, Irvine, California, United States of America

Corresponding Author

Email: emmaw@ucr.edu

Competing Interests

LF and CH are employed by Pfizer. This does not alter our adherence to all PLOS Pathogens policies on sharing data and materials. All other authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: JPN KMV TAW EHW. Performed the experiments: JPN DW CD KMV SN. Analyzed the data: JPN DW CD KMV DC SN CH LF TEL TAW EHW. Contributed reagents/materials/analysis tools: KMV DC CH LF TEL TAW. Wrote the paper: JPN KMV EHW. Provided the AMCase null mice: CH LF.