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Research Article

The Polymorphic Pseudokinase ROP5 Controls Virulence in Toxoplasma gondii by Regulating the Active Kinase ROP18

  • Michael S. Behnke equal contributor,

    equal contributor Contributed equally to this work with: Michael S. Behnke, Sarah J. Fentress

    Affiliation: Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, Missouri, United States of America

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  • Sarah J. Fentress equal contributor,

    equal contributor Contributed equally to this work with: Michael S. Behnke, Sarah J. Fentress

    Affiliation: Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, Missouri, United States of America

    X
  • Mona Mashayekhi,

    Affiliation: Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri, United States of America

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  • Lucy X. Li,

    Affiliation: Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, Missouri, United States of America

    X
  • Gregory A. Taylor,

    Affiliations: Departments of Medicine, Molecular Genetics and Microbiology, and Immunology, Division of Geriatrics, and Center for the Study of Aging and Human Development, Duke University Medical Center, Durham, North Carolina, United States of America, Geriatric Research, Education, and Clinical Center, VA Medical Center, Durham, North Carolina, United States of America

    X
  • L. David Sibley mail

    sibley@wustl.edu

    Affiliation: Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, Missouri, United States of America

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  • Published: November 08, 2012
  • DOI: 10.1371/journal.ppat.1002992

About the Authors

Michael S. Behnke, Sarah J. Fentress, Lucy X. Li, L. David Sibley
Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, Missouri, United States of America
Mona Mashayekhi
Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri, United States of America
Gregory A. Taylor
Departments of Medicine, Molecular Genetics and Microbiology, and Immunology, Division of Geriatrics, and Center for the Study of Aging and Human Development, Duke University Medical Center, Durham, North Carolina, United States of America
Gregory A. Taylor
Geriatric Research, Education, and Clinical Center, VA Medical Center, Durham, North Carolina, United States of America

Corresponding Author

Email: sibley@wustl.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: MSB SJF MM LXL LDS. Performed the experiments: MSB SJF MM LXL. Analyzed the data: MSB SJF MM LXL LDS. Contributed reagents/materials/analysis tools: GAT. Wrote the paper: MSB SJF GAT LDS.