Advertisement
Research Article

Structural and Functional Insights into the HIV-1 Maturation Inhibitor Binding Pocket

  • Kayoko Waki,

    Affiliation: Virus-Cell Interaction Section, HIV Drug Resistance Program, Frederick National Laboratory for Cancer Research, National Cancer Institute, Frederick, Maryland, United States of America

    X
  • Stewart R. Durell,

    Affiliation: Laboratory of Cell Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America

    X
  • Ferri Soheilian,

    Affiliation: Electron Microscope Laboratory, Advanced Technology Program, SAIC-Frederick, Frederick National Laboratory for Cancer Research, National Cancer Institute, Frederick, Maryland, United States of America

    X
  • Kunio Nagashima,

    Affiliation: Electron Microscope Laboratory, Advanced Technology Program, SAIC-Frederick, Frederick National Laboratory for Cancer Research, National Cancer Institute, Frederick, Maryland, United States of America

    X
  • Scott L. Butler,

    Affiliation: Antiviral Biology, Pfizer Global Research & Development, Sandwich Laboratories, Sandwich, Kent, United Kingdom

    Current address: Infection Innovative Medicine, AstraZeneca Pharmaceuticals, Waltham, Massachusetts, United States of America

    X
  • Eric O. Freed mail

    efreed@nih.gov

    Affiliation: Virus-Cell Interaction Section, HIV Drug Resistance Program, Frederick National Laboratory for Cancer Research, National Cancer Institute, Frederick, Maryland, United States of America

    X
  • Published: November 08, 2012
  • DOI: 10.1371/journal.ppat.1002997

About the Authors

Kayoko Waki, Eric O. Freed
Virus-Cell Interaction Section, HIV Drug Resistance Program, Frederick National Laboratory for Cancer Research, National Cancer Institute, Frederick, Maryland, United States of America
Stewart R. Durell
Laboratory of Cell Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America
Ferri Soheilian, Kunio Nagashima
Electron Microscope Laboratory, Advanced Technology Program, SAIC-Frederick, Frederick National Laboratory for Cancer Research, National Cancer Institute, Frederick, Maryland, United States of America
Scott L. Butler
Antiviral Biology, Pfizer Global Research & Development, Sandwich Laboratories, Sandwich, Kent, United Kingdom

Corresponding Author

Email: efreed@nih.gov

Competing Interests

I have read the journal's policy and have the following conflicts: One of the authors (Scott Butler) is a former employee of Pfizer. This does not alter our adherence to all PLoS Pathogens policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: KW SLB EOF. Performed the experiments: KW FS KN. Analyzed the data: KW SRD FS KN SLB EOF. Contributed reagents/materials/analysis tools: SRD SLB. Wrote the paper: KW EOF.