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Research Article

Therapeutic Helminth Infection of Macaques with Idiopathic Chronic Diarrhea Alters the Inflammatory Signature and Mucosal Microbiota of the Colon

  • Mara Jana Broadhurst mail,

    mara.broadhurst@ucsf.edu (MJB); Png.loke@nyumc.org (PL)

    Affiliation: Division of Experimental Medicine, Department of Medicine, University of California San Francisco, San Francisco, California, United States of America

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  • Amir Ardeshir,

    Affiliation: California National Primate Research Center, Davis, California, United States of America

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  • Bittoo Kanwar,

    Affiliation: Division of Experimental Medicine, Department of Medicine, University of California San Francisco, San Francisco, California, United States of America

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  • Julie Mirpuri,

    Affiliation: Department of Immunology, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America

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  • Uma Mahesh Gundra,

    Affiliation: Department of Microbiology, New York University, New York, New York, United States of America

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  • Jacqueline M. Leung,

    Affiliation: Department of Microbiology, New York University, New York, New York, United States of America

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  • Kirsten E. Wiens,

    Affiliation: Department of Microbiology, New York University, New York, New York, United States of America

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  • Ivan Vujkovic-Cvijin,

    Affiliation: Division of Experimental Medicine, Department of Medicine, University of California San Francisco, San Francisco, California, United States of America

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  • Charlie C. Kim,

    Affiliation: Division of Experimental Medicine, Department of Medicine, University of California San Francisco, San Francisco, California, United States of America

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  • Felix Yarovinsky,

    Affiliation: Department of Immunology, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America

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  • Nicholas W. Lerche †,

    † Deceased.

    Affiliation: California National Primate Research Center, Davis, California, United States of America

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  • Joseph M. McCune,

    Affiliation: Division of Experimental Medicine, Department of Medicine, University of California San Francisco, San Francisco, California, United States of America

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  • P'ng Loke mail

    mara.broadhurst@ucsf.edu (MJB); Png.loke@nyumc.org (PL)

    Affiliation: Department of Microbiology, New York University, New York, New York, United States of America

    X
  • Published: November 15, 2012
  • DOI: 10.1371/journal.ppat.1003000

About the Authors

Mara Jana Broadhurst, Bittoo Kanwar, Ivan Vujkovic-Cvijin, Charlie C. Kim, Joseph M. McCune
Division of Experimental Medicine, Department of Medicine, University of California San Francisco, San Francisco, California, United States of America
Amir Ardeshir, Nicholas W. Lerche
California National Primate Research Center, Davis, California, United States of America
Julie Mirpuri, Felix Yarovinsky
Department of Immunology, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America
Uma Mahesh Gundra, Jacqueline M. Leung, Kirsten E. Wiens, P'ng Loke
Department of Microbiology, New York University, New York, New York, United States of America

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: MJB FY NWL JMM PL. Performed the experiments: MJB AA BK JM UMG JML IVC. Analyzed the data: MJB JM KEW CCK FY NWL JMM PL. Wrote the paper: MJB KEW JMM PL.