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Research Article

Early Mechanisms of Pathobiology Are Revealed by Transcriptional Temporal Dynamics in Hippocampal CA1 Neurons of Prion Infected Mice

  • Anna Majer,

    Affiliations: Molecular PathoBiology, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba, Canada, Department of Medical Microbiology and Infectious Diseases, University of Manitoba, Winnipeg, Manitoba, Canada

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  • Sarah J. Medina,

    Affiliation: Molecular PathoBiology, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba, Canada

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  • Yulian Niu,

    Affiliation: Molecular PathoBiology, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba, Canada

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  • Bernard Abrenica,

    Affiliation: Molecular PathoBiology, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba, Canada

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  • Kathy J. Manguiat,

    Affiliation: Molecular PathoBiology, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba, Canada

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  • Kathy L. Frost,

    Affiliation: Molecular PathoBiology, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba, Canada

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  • Clark S. Philipson,

    Affiliation: Molecular PathoBiology, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba, Canada

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  • Debra L. Sorensen,

    Affiliation: Molecular PathoBiology, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba, Canada

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  • Stephanie A. Booth mail

    Stephanie.Booth@phac-aspc.gc.ca

    Affiliations: Molecular PathoBiology, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba, Canada, Department of Medical Microbiology and Infectious Diseases, University of Manitoba, Winnipeg, Manitoba, Canada

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  • Published: November 08, 2012
  • DOI: 10.1371/journal.ppat.1003002

About the Authors

Anna Majer, Sarah J. Medina, Yulian Niu, Bernard Abrenica, Kathy J. Manguiat, Kathy L. Frost, Clark S. Philipson, Debra L. Sorensen, Stephanie A. Booth
Molecular PathoBiology, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba, Canada
Anna Majer, Stephanie A. Booth
Department of Medical Microbiology and Infectious Diseases, University of Manitoba, Winnipeg, Manitoba, Canada

Corresponding Author

Email: Stephanie.Booth@phac-aspc.gc.ca

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: SAB AM. Performed the experiments: AM SJM YN BA KJM KLF CSP DLS. Analyzed the data: SAB AM BA. Wrote the paper: SAB AM BA.