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Research Article

Changes in JC Virus-Specific T Cell Responses during Natalizumab Treatment and in Natalizumab-Associated Progressive Multifocal Leukoencephalopathy

  • Molly R. Perkins,

    Affiliations: Human Immunology Section, Vaccine Research Center, National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, Maryland, United States of America, MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, United Kingdom

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  • Caroline Ryschkewitsch,

    Affiliation: Laboratory of Molecular Medicine and Neuroscience, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, United States of America

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  • Julia C. Liebner,

    Affiliation: Human Immunology Section, Vaccine Research Center, National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, Maryland, United States of America

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  • Maria Chiara G. Monaco,

    Affiliation: Laboratory of Molecular Medicine and Neuroscience, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, United States of America

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  • Danielle Himelfarb,

    Affiliation: Human Immunology Section, Vaccine Research Center, National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, Maryland, United States of America

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  • Sara Ireland,

    Affiliation: Department of Neurology, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America

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  • Annelys Roque,

    Affiliation: Human Immunology Section, Vaccine Research Center, National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, Maryland, United States of America

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  • Heather L. Edward,

    Affiliation: Human Immunology Section, Vaccine Research Center, National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, Maryland, United States of America

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  • Peter N. Jensen,

    Affiliation: Laboratory of Molecular Medicine and Neuroscience, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, United States of America

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  • Gina Remington,

    Affiliation: Department of Neurology, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America

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  • Thomas Abraham,

    Affiliation: Department of Neurology, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America

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  • Jaspreet Abraham,

    Affiliation: Department of Neurology, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America

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  • Benjamin Greenberg,

    Affiliation: Department of Neurology, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America

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  • Charles Kaufman,

    Affiliation: Louisiana Neurologic Consultants. Baton Rouge, Louisiana, United States of America

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  • Chris LaGanke,

    Affiliation: North Central Neurology, Cullman, Alabama, United States of America

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  • Nancy L. Monson,

    Affiliation: Department of Neurology, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America

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  • Xiaoning Xu,

    Affiliation: MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, United Kingdom

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  • Elliot Frohman,

    Affiliation: Department of Neurology, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America

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  • Eugene O. Major mail,

    majorg@ninds.nih.gov (EOM); ddouek@mail.nih.gov (DCD)

    Affiliation: Laboratory of Molecular Medicine and Neuroscience, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, United States of America

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  • Daniel C. Douek mail

    majorg@ninds.nih.gov (EOM); ddouek@mail.nih.gov (DCD)

    Affiliation: Human Immunology Section, Vaccine Research Center, National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, Maryland, United States of America

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  • Published: November 08, 2012
  • DOI: 10.1371/journal.ppat.1003014

About the Authors

Molly R. Perkins, Julia C. Liebner, Danielle Himelfarb, Annelys Roque, Heather L. Edward, Daniel C. Douek
Human Immunology Section, Vaccine Research Center, National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, Maryland, United States of America
Molly R. Perkins, Xiaoning Xu
MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, United Kingdom
Caroline Ryschkewitsch, Maria Chiara G. Monaco, Peter N. Jensen, Eugene O. Major
Laboratory of Molecular Medicine and Neuroscience, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, United States of America
Sara Ireland, Gina Remington, Thomas Abraham, Jaspreet Abraham, Benjamin Greenberg, Nancy L. Monson, Elliot Frohman
Department of Neurology, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America
Charles Kaufman
Louisiana Neurologic Consultants. Baton Rouge, Louisiana, United States of America
Chris LaGanke
North Central Neurology, Cullman, Alabama, United States of America

Corresponding Authors

Competing Interests

I have read the journal's policy and have the following conflicts: Dr. Greenberg has received honoraria from the MSAA. He has received consulting fees from Sanofi Aventis, The Greater Good Foundation, Biogen Idec, Elan, Applied Clinical Intelligence and DioGenix. He holds equity in DioGenix, Inc. He receives grant support from the Guthy Jackson Charitable Foundation, Amplimmune and Accelerated Cure Project. Dr. Frohman has received speaker and consulting fees from Biogen Idec, TEVA, Novartis, and Acorda; and consulting fees from Abbott and Genzyme. This does not alter our adherence to all PLoS Pathogens policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: BG DCD EF EOM MRP XX. Performed the experiments: AR CK CL CR DH GR HLE JA JCL MCGM MRP PNJ SI TA. Analyzed the data: CK CL CR GR JA JCL MCGM MRP NLM TA. Wrote the paper: DCD EOM MRP. Gathered patient data and samples: BG CK CL CR EOM EF GR JA NM TA.