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Research Article

The Quorum Sensing Volatile Molecule 2-Amino Acetophenon Modulates Host Immune Responses in a Manner that Promotes Life with Unwanted Guests

  • Arunava Bandyopadhaya equal contributor,

    equal contributor Contributed equally to this work with: Arunava Bandyopadhaya, Meenu Kesarwani

    Affiliations: Department of Surgery, Harvard Medical School and Massachusetts General Hospital, Boston, Massachusetts, United States of America, Department of Microbiology and Immunobiology, Harvard Medical School, Boston, Massachusetts, United States of America, Shriners Hospitals for Children Boston, Boston, Massachusetts, United States of America

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  • Meenu Kesarwani equal contributor,

    equal contributor Contributed equally to this work with: Arunava Bandyopadhaya, Meenu Kesarwani

    Affiliations: Department of Surgery, Harvard Medical School and Massachusetts General Hospital, Boston, Massachusetts, United States of America, Department of Microbiology and Immunobiology, Harvard Medical School, Boston, Massachusetts, United States of America, Shriners Hospitals for Children Boston, Boston, Massachusetts, United States of America

    Current address: Cincinnati Children's Hospital and Medical Center, Cincinnati, Ohio, United States of America.

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  • Yok-Ai Que,

    Affiliations: Department of Surgery, Harvard Medical School and Massachusetts General Hospital, Boston, Massachusetts, United States of America, Department of Microbiology and Immunobiology, Harvard Medical School, Boston, Massachusetts, United States of America, Shriners Hospitals for Children Boston, Boston, Massachusetts, United States of America

    X
  • Jianxin He,

    Affiliations: Department of Surgery, Harvard Medical School and Massachusetts General Hospital, Boston, Massachusetts, United States of America, Department of Microbiology and Immunobiology, Harvard Medical School, Boston, Massachusetts, United States of America, Shriners Hospitals for Children Boston, Boston, Massachusetts, United States of America

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  • Katie Padfield,

    Affiliations: Department of Surgery, Harvard Medical School and Massachusetts General Hospital, Boston, Massachusetts, United States of America, Shriners Hospitals for Children Boston, Boston, Massachusetts, United States of America

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  • Ronald Tompkins,

    Affiliations: Department of Surgery, Harvard Medical School and Massachusetts General Hospital, Boston, Massachusetts, United States of America, Shriners Hospitals for Children Boston, Boston, Massachusetts, United States of America

    X
  • Laurence G. Rahme mail

    rahme@molbio.mgh.harvard.edu

    Affiliations: Department of Surgery, Harvard Medical School and Massachusetts General Hospital, Boston, Massachusetts, United States of America, Department of Microbiology and Immunobiology, Harvard Medical School, Boston, Massachusetts, United States of America, Shriners Hospitals for Children Boston, Boston, Massachusetts, United States of America

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  • Published: November 15, 2012
  • DOI: 10.1371/journal.ppat.1003024

About the Authors

Arunava Bandyopadhaya, Meenu Kesarwani, Yok-Ai Que, Jianxin He, Katie Padfield, Ronald Tompkins, Laurence G. Rahme
Department of Surgery, Harvard Medical School and Massachusetts General Hospital, Boston, Massachusetts, United States of America
Arunava Bandyopadhaya, Meenu Kesarwani, Yok-Ai Que, Jianxin He, Laurence G. Rahme
Department of Microbiology and Immunobiology, Harvard Medical School, Boston, Massachusetts, United States of America
Arunava Bandyopadhaya, Meenu Kesarwani, Yok-Ai Que, Jianxin He, Katie Padfield, Ronald Tompkins, Laurence G. Rahme
Shriners Hospitals for Children Boston, Boston, Massachusetts, United States of America

Corresponding Author

Email: rahme@molbio.mgh.harvard.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: AB MK LGR. Performed the experiments: AB MK YQ JH KP. Analyzed the data: AB MK LGR. Contributed reagents/materials/analysis tools: LGR RT. Wrote the paper: AB MK LGR.