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Research Article

Heterotrimeric G-protein Signaling Is Critical to Pathogenic Processes in Entamoeba histolytica

  • Dustin E. Bosch equal contributor,

    equal contributor Contributed equally to this work with: Dustin E. Bosch, Adam J. Kimple

    Affiliation: Department of Pharmacology, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America

    X
  • Adam J. Kimple equal contributor,

    equal contributor Contributed equally to this work with: Dustin E. Bosch, Adam J. Kimple

    Affiliation: Department of Pharmacology, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America

    X
  • Robin E. Muller,

    Affiliation: Department of Pharmacology, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America

    X
  • Patrick M. Giguère,

    Affiliation: Department of Pharmacology, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America

    X
  • Mischa Machius,

    Affiliation: Department of Pharmacology, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America

    X
  • Francis S. Willard,

    Affiliation: Department of Pharmacology, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America

    Current address: Lilly Research Laboratories, Eli Lilly and Co., Indianapolis, Indiana, United States of America.

    X
  • Brenda R. S. Temple,

    Affiliations: Department of Biochemistry & Biophysics, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America, R. L. Juliano Structural Bioinformatics Core, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America

    X
  • David P. Siderovski mail

    dpsiderovski@hsc.wvu.edu

    Affiliation: Department of Physiology & Pharmacology, West Virginia University School of Medicine, Robert C. Byrd Health Sciences Center, Morgantown, West Virginia, United States of America

    X
  • Published: November 15, 2012
  • DOI: 10.1371/journal.ppat.1003040

About the Authors

Dustin E. Bosch, Adam J. Kimple, Robin E. Muller, Patrick M. Giguère, Mischa Machius, Francis S. Willard
Department of Pharmacology, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America
Brenda R. S. Temple
Department of Biochemistry & Biophysics, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America
Brenda R. S. Temple
R. L. Juliano Structural Bioinformatics Core, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America
David P. Siderovski
Department of Physiology & Pharmacology, West Virginia University School of Medicine, Robert C. Byrd Health Sciences Center, Morgantown, West Virginia, United States of America

Corresponding Author

Email: dpsiderovski@hsc.wvu.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: DEB AJK FSW DPS. Performed the experiments: DEB AJK REM PMG MM BRST. Analyzed the data: DEB AJK REM MM BRST DPS. Contributed reagents/materials/analysis tools: MM. Wrote the paper: DEB AJK DPS.