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Research Article

Role of Transmitted Gag CTL Polymorphisms in Defining Replicative Capacity and Early HIV-1 Pathogenesis

  • Jessica L. Prince equal contributor,

    equal contributor Contributed equally to this work with: Jessica L. Prince, Daniel T. Claiborne

    Affiliation: Emory Vaccine Center at Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, United States of America

    X
  • Daniel T. Claiborne equal contributor,

    equal contributor Contributed equally to this work with: Jessica L. Prince, Daniel T. Claiborne

    Affiliation: Emory Vaccine Center at Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, United States of America

    X
  • Jonathan M. Carlson,

    Affiliation: Microsoft Research, Los Angeles, California, United States of America

    X
  • Malinda Schaefer,

    Affiliation: Emory Vaccine Center at Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, United States of America

    X
  • Tianwei Yu,

    Affiliation: Department of Biostatistics and Bioinformatics, Emory University, Atlanta, Georgia, United States of America

    X
  • Shabir Lahki,

    Affiliation: Zambia-Emory HIV Research Project, Lusaka, Zambia

    X
  • Heather A. Prentice,

    Affiliation: Department of Epidemiology, University of Alabama, Birmingham, Alabama, United States of America

    X
  • Ling Yue,

    Affiliation: Emory Vaccine Center at Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, United States of America

    X
  • Sundaram A. Vishwanathan,

    Affiliation: Emory Vaccine Center at Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, United States of America

    Current address: Laboratory branch, Division of HIV/AIDS Prevention, NCHHSTP, Centers for Disease Control & Prevention, Atlanta, Georgia, United States of America.

    X
  • William Kilembe,

    Affiliation: Zambia-Emory HIV Research Project, Lusaka, Zambia

    X
  • Paul Goepfert,

    Affiliation: Department of Medicine, University of Alabama, Birmingham, Alabama, United States of America

    X
  • Matthew A. Price,

    Affiliation: International AIDS Vaccine Initiative, San Francisco, California, United States of America

    X
  • Jill Gilmour,

    Affiliation: International AIDS Vaccine Initiative, London, England

    X
  • Joseph Mulenga,

    Affiliation: Zambia-Emory HIV Research Project, Lusaka, Zambia

    X
  • Paul Farmer,

    Affiliation: Emory Vaccine Center at Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, United States of America

    X
  • Cynthia A. Derdeyn,

    Affiliations: Emory Vaccine Center at Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, United States of America, Department of Pathology and Laboratory Medicine, Emory University, Atlanta, Georgia, United States of America

    X
  • Jiaming Tang,

    Affiliation: Department of Medicine, University of Alabama, Birmingham, Alabama, United States of America

    X
  • David Heckerman,

    Affiliation: Microsoft Research, Los Angeles, California, United States of America

    X
  • Richard A. Kaslow,

    Affiliation: Department of Epidemiology, University of Alabama, Birmingham, Alabama, United States of America

    X
  • Susan A. Allen,

    Affiliations: Zambia-Emory HIV Research Project, Lusaka, Zambia, Department of Pathology and Laboratory Medicine, Emory University, Atlanta, Georgia, United States of America, Department of Global Health, Rollins School of Public Health, Emory University, Atlanta, Georgia, United States of America

    X
  • Eric Hunter mail

    ehunte4@emory.edu

    Affiliations: Emory Vaccine Center at Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, United States of America, Department of Pathology and Laboratory Medicine, Emory University, Atlanta, Georgia, United States of America

    X
  • Published: November 29, 2012
  • DOI: 10.1371/journal.ppat.1003041

About the Authors

Jessica L. Prince, Daniel T. Claiborne, Malinda Schaefer, Ling Yue, Sundaram A. Vishwanathan, Paul Farmer, Cynthia A. Derdeyn, Eric Hunter
Emory Vaccine Center at Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, United States of America
Jonathan M. Carlson, David Heckerman
Microsoft Research, Los Angeles, California, United States of America
Tianwei Yu
Department of Biostatistics and Bioinformatics, Emory University, Atlanta, Georgia, United States of America
Shabir Lahki, William Kilembe, Joseph Mulenga, Susan A. Allen
Zambia-Emory HIV Research Project, Lusaka, Zambia
Heather A. Prentice, Richard A. Kaslow
Department of Epidemiology, University of Alabama, Birmingham, Alabama, United States of America
Paul Goepfert, Jiaming Tang
Department of Medicine, University of Alabama, Birmingham, Alabama, United States of America
Matthew A. Price
International AIDS Vaccine Initiative, San Francisco, California, United States of America
Jill Gilmour
International AIDS Vaccine Initiative, London, England
Cynthia A. Derdeyn, Susan A. Allen, Eric Hunter
Department of Pathology and Laboratory Medicine, Emory University, Atlanta, Georgia, United States of America
Susan A. Allen
Department of Global Health, Rollins School of Public Health, Emory University, Atlanta, Georgia, United States of America

Corresponding Author

Email: ehunte4@emory.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: EH DTC JLP SAV PG JMC. Performed the experiments: DTC JLP MS. Analyzed the data: EH DTC JLP JMC DH TY JT RAK MAP HAP PG SAA. Contributed reagents/materials/analysis tools: LY PF RAK JT SL JM WK JG SAA. Wrote the paper: DTC JLP EH CAD JMC. Were critically involved in sample collection, site maintenance, participant recruitment and follow-up: SL JM WK JG SAA.