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Research Article

Rapid Antigen Processing and Presentation of a Protective and Immunodominant HLA-B*27-restricted Hepatitis C Virus-specific CD8+ T-cell Epitope

  • Julia Schmidt,

    Affiliations: Department of Medicine II, University Hospital Freiburg, Freiburg, Germany, Faculty of Biology, University of Freiburg, Freiburg, Germany, Centre of Chronic Immunodeficiency, University of Freiburg, Freiburg, Germany

    X
  • Astrid K. N. Iversen mail,

    astrid.iversen@ndcn.ox.ac.uk (AKNI); robert.thimme@uniklinik-freiburg.de (RT)

    Affiliation: Nuffield Department of Clinical Neurosciences, Division of Clinical Neurology, Weatherall Institute of Molecular Medicine, Oxford University, Oxford, United Kingdom

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  • Stefan Tenzer,

    Affiliation: Institute of Immunology, University Medical Center of the Johannes Gutenberg University of Mainz, Mainz, Germany

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  • Emma Gostick,

    Affiliation: Institute of Infection and Immunity, Cardiff University School of Medicine, Cardiff, United Kingdom

    X
  • David A. Price,

    Affiliation: Institute of Infection and Immunity, Cardiff University School of Medicine, Cardiff, United Kingdom

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  • Volker Lohmann,

    Affiliation: Department of Infectious Diseases, University of Heidelberg, Heidelberg, Germany

    X
  • Ute Distler,

    Affiliation: Institute of Immunology, University Medical Center of the Johannes Gutenberg University of Mainz, Mainz, Germany

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  • Paul Bowness,

    Affiliations: Medical Research Council Human Immunology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Oxford, United Kingdom, Nuffield Department of Clinical Medicine, Oxford, United Kingdom

    X
  • Hansjörg Schild,

    Affiliation: Institute of Immunology, University Medical Center of the Johannes Gutenberg University of Mainz, Mainz, Germany

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  • Hubert E. Blum,

    Affiliation: Department of Medicine II, University Hospital Freiburg, Freiburg, Germany

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  • Paul Klenerman,

    Affiliation: Nuffield Department of Clinical Medicine, Oxford, United Kingdom

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  • Christoph Neumann-Haefelin equal contributor,

    equal contributor Contributed equally to this work with: Christoph Neumann-Haefelin, Robert Thimme

    Affiliation: Department of Medicine II, University Hospital Freiburg, Freiburg, Germany

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  • Robert Thimme equal contributor mail

    equal contributor Contributed equally to this work with: Christoph Neumann-Haefelin, Robert Thimme

    astrid.iversen@ndcn.ox.ac.uk (AKNI); robert.thimme@uniklinik-freiburg.de (RT)

    Affiliation: Department of Medicine II, University Hospital Freiburg, Freiburg, Germany

    X
  • Published: November 29, 2012
  • DOI: 10.1371/journal.ppat.1003042

About the Authors

Julia Schmidt, Hubert E. Blum, Christoph Neumann-Haefelin, Robert Thimme
Department of Medicine II, University Hospital Freiburg, Freiburg, Germany
Julia Schmidt
Faculty of Biology, University of Freiburg, Freiburg, Germany
Julia Schmidt
Centre of Chronic Immunodeficiency, University of Freiburg, Freiburg, Germany
Astrid K. N. Iversen
Nuffield Department of Clinical Neurosciences, Division of Clinical Neurology, Weatherall Institute of Molecular Medicine, Oxford University, Oxford, United Kingdom
Stefan Tenzer, Ute Distler, Hansjörg Schild
Institute of Immunology, University Medical Center of the Johannes Gutenberg University of Mainz, Mainz, Germany
Emma Gostick, David A. Price
Institute of Infection and Immunity, Cardiff University School of Medicine, Cardiff, United Kingdom
Volker Lohmann
Department of Infectious Diseases, University of Heidelberg, Heidelberg, Germany
Paul Bowness
Medical Research Council Human Immunology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Oxford, United Kingdom
Paul Bowness, Paul Klenerman
Nuffield Department of Clinical Medicine, Oxford, United Kingdom

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: JS AKNI ST PK CNH RT. Performed the experiments: JS ST UD. Analyzed the data: JS AKNI ST CNH. Contributed reagents/materials/analysis tools: EG DAP VL PB HS HEB. Wrote the paper: JS AKNI ST DAP PK CNH RT.