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Research Article

Neutrophil-derived IL-1β Is Sufficient for Abscess Formation in Immunity against Staphylococcus aureus in Mice

  • John S. Cho,

    Affiliation: Department of Medicine, Division of Dermatology, David Geffen School of Medicine at University of California Los Angeles (UCLA), Los Angeles, California, United States of America

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  • Yi Guo,

    Affiliation: Department of Medicine, Division of Dermatology, David Geffen School of Medicine at University of California Los Angeles (UCLA), Los Angeles, California, United States of America

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  • Romela Irene Ramos,

    Affiliation: Department of Medicine, Division of Dermatology, David Geffen School of Medicine at University of California Los Angeles (UCLA), Los Angeles, California, United States of America

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  • Frank Hebroni,

    Affiliation: Department of Medicine, Division of Dermatology, David Geffen School of Medicine at University of California Los Angeles (UCLA), Los Angeles, California, United States of America

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  • Seema B. Plaisier,

    Affiliation: Department of Translational Immunology, Dirks/Dougherty Laboratory for Cancer Research, John Wayne Cancer Institute, Santa Monica, California, United States of America

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  • Caiyun Xuan,

    Affiliation: Department of Translational Immunology, Dirks/Dougherty Laboratory for Cancer Research, John Wayne Cancer Institute, Santa Monica, California, United States of America

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  • Jennifer L. Granick,

    Affiliation: Department of Biomedical Engineering, University of California Davis, Davis, California, United States of America

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  • Hironori Matsushima,

    Affiliation: Department of Medical Microbiology and Immunology, University of Toledo College of Medicine, Toledo, Ohio, United States of America

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  • Akira Takashima,

    Affiliation: Department of Medical Microbiology and Immunology, University of Toledo College of Medicine, Toledo, Ohio, United States of America

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  • Yoichiro Iwakura,

    Affiliation: Center for Experimental Medicine and Systems Biology, Institute of Medical Science, University of Tokyo, Minato-ku, Tokyo, Japan and Core Research for Evolutional Science and Technology (CREST), Japan Science and Technology Agency, Saitama, Japan

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  • Ambrose L. Cheung,

    Affiliation: Department of Microbiology and Immunology, Dartmouth Medical School, Hanover, New Hampshire, United States of America

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  • Genhong Cheng,

    Affiliation: Department of Microbiology, Immunology, and Molecular Genetics, David Geffen School of Medicine at University of California Los Angeles (UCLA), Los Angeles, California, United States of America

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  • Delphine J. Lee,

    Affiliation: Department of Translational Immunology, Dirks/Dougherty Laboratory for Cancer Research, John Wayne Cancer Institute, Santa Monica, California, United States of America

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  • Scott I. Simon,

    Affiliation: Department of Biomedical Engineering, University of California Davis, Davis, California, United States of America

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  • Lloyd S. Miller mail

    lloydmiller@jhmi.edu

    Affiliation: Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America

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  • Published: November 29, 2012
  • DOI: 10.1371/journal.ppat.1003047

About the Authors

John S. Cho, Yi Guo, Romela Irene Ramos, Frank Hebroni
Department of Medicine, Division of Dermatology, David Geffen School of Medicine at University of California Los Angeles (UCLA), Los Angeles, California, United States of America
Seema B. Plaisier, Caiyun Xuan, Delphine J. Lee
Department of Translational Immunology, Dirks/Dougherty Laboratory for Cancer Research, John Wayne Cancer Institute, Santa Monica, California, United States of America
Jennifer L. Granick, Scott I. Simon
Department of Biomedical Engineering, University of California Davis, Davis, California, United States of America
Hironori Matsushima, Akira Takashima
Department of Medical Microbiology and Immunology, University of Toledo College of Medicine, Toledo, Ohio, United States of America
Yoichiro Iwakura
Center for Experimental Medicine and Systems Biology, Institute of Medical Science, University of Tokyo, Minato-ku, Tokyo, Japan and Core Research for Evolutional Science and Technology (CREST), Japan Science and Technology Agency, Saitama, Japan
Ambrose L. Cheung
Department of Microbiology and Immunology, Dartmouth Medical School, Hanover, New Hampshire, United States of America
Genhong Cheng
Department of Microbiology, Immunology, and Molecular Genetics, David Geffen School of Medicine at University of California Los Angeles (UCLA), Los Angeles, California, United States of America
Lloyd S. Miller
Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America

Corresponding Author

Email: lloydmiller@jhmi.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: JSC DJL SIS LSM. Performed the experiments: JSC YG RIR FH SBP CX JLG HM. Analyzed the data: JSC LSM YG RIR FH CX SBP DJL. Contributed reagents/materials/analysis tools: SBP HM ALC AT YI ALC GC DJL. Wrote the paper: JSC LSM. Performed the analysis of the microarray data: SBP DJL. Provided expertise and helped perform experiments with fluorescence reporter mice: HM AT SIS. Generated and provided technical assistance with the bacterial strain used in this study: ALC. Provided reagents, intellectual input, and technical assistance: YI GC.