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Research Article

Hsp90 Inhibitors Are Efficacious against Kaposi Sarcoma by Enhancing the Degradation of the Essential Viral Gene LANA, of the Viral Co-Receptor EphA2 as well as Other Client Proteins

  • Wuguo Chen,
  • Sang-Hoon Sin,
  • Kwun Wah Wen,
  • Blossom Damania,
  • Dirk P. Dittmer mail

    ddittmer@med.unc.edu

    Affiliation: Department of Microbiology and Immunology, Program in Global Oncology, Lineberger Comprehensive Cancer Center, Center for AIDS Research, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America

    X
  • Published: November 29, 2012
  • DOI: 10.1371/journal.ppat.1003048

About the Authors

Dirk P. Dittmer
Department of Microbiology and Immunology, Program in Global Oncology, Lineberger Comprehensive Cancer Center, Center for AIDS Research, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America

Corresponding Author

Email: ddittmer@med.unc.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: WC DPD BD. Performed the experiments: WC S-HS. Analyzed the data: WC DPD BD S-HS. Contributed reagents/materials/analysis tools: KWW. Wrote the paper: WC DPD BD.