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Research Article

Three-Dimensional Architecture and Biogenesis of Membrane Structures Associated with Hepatitis C Virus Replication

  • Inés Romero-Brey,

    Affiliation: Department of Infectious Diseases, Molecular Virology, University of Heidelberg, Heidelberg, Germany

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  • Andreas Merz,

    Affiliation: Department of Infectious Diseases, Molecular Virology, University of Heidelberg, Heidelberg, Germany

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  • Abhilash Chiramel,

    Affiliation: Department of Infectious Diseases, Molecular Virology, University of Heidelberg, Heidelberg, Germany

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  • Ji-Young Lee,

    Affiliation: Department of Infectious Diseases, Molecular Virology, University of Heidelberg, Heidelberg, Germany

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  • Petr Chlanda,

    Affiliation: European Molecular Biology Laboratory, Heidelberg, Germany

    Current address: Program in Physical Biology, Eunice Kennedy Schriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, United States of America.

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  • Uta Haselman,

    Affiliation: European Molecular Biology Laboratory, Heidelberg, Germany

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  • Rachel Santarella-Mellwig,

    Affiliation: European Molecular Biology Laboratory, Heidelberg, Germany

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  • Anja Habermann,

    Affiliation: Electron Microscopy Core Facility, University of Heidelberg, Heidelberg, Germany

    Current address: Johann Wolfgang Goethe University Frankfurt, Institute of Biophysics, Frankfurt am Main, Germany.

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  • Simone Hoppe,

    Affiliations: Department of Infectious Diseases, Molecular Virology, University of Heidelberg, Heidelberg, Germany, Electron Microscopy Core Facility, University of Heidelberg, Heidelberg, Germany

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  • Stephanie Kallis,

    Affiliation: Department of Infectious Diseases, Molecular Virology, University of Heidelberg, Heidelberg, Germany

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  • Paul Walther,

    Affiliation: Central Electron Microscopy Facility, Ulm University, Ulm, Germany

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  • Claude Antony,

    Affiliation: European Molecular Biology Laboratory, Heidelberg, Germany

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  • Jacomine Krijnse-Locker,

    Affiliations: Department of Infectious Diseases, Molecular Virology, University of Heidelberg, Heidelberg, Germany, Electron Microscopy Core Facility, University of Heidelberg, Heidelberg, Germany

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  • Ralf Bartenschlager mail

    Ralf_Bartenschlager@med.uni-heidelberg.de

    Affiliation: Department of Infectious Diseases, Molecular Virology, University of Heidelberg, Heidelberg, Germany

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  • Published: December 06, 2012
  • DOI: 10.1371/journal.ppat.1003056

About the Authors

Inés Romero-Brey, Andreas Merz, Abhilash Chiramel, Ji-Young Lee, Simone Hoppe, Stephanie Kallis, Jacomine Krijnse-Locker, Ralf Bartenschlager
Department of Infectious Diseases, Molecular Virology, University of Heidelberg, Heidelberg, Germany
Petr Chlanda, Uta Haselman, Rachel Santarella-Mellwig, Claude Antony
European Molecular Biology Laboratory, Heidelberg, Germany
Anja Habermann, Simone Hoppe, Jacomine Krijnse-Locker
Electron Microscopy Core Facility, University of Heidelberg, Heidelberg, Germany
Paul Walther
Central Electron Microscopy Facility, Ulm University, Ulm, Germany

Corresponding Author

Email: Ralf_Bartenschlager@med.uni-heidelberg.de

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: IR-B AM AC J-YL PC JK-L RB. Performed the experiments: IR-B AM AC J-YL UH RS-M PC AH SH SK JK-L. Analyzed the data: IR-B AM AC J-YL PC PW JK-L RB. Contributed reagents/materials/analysis tools: CA. Wrote the paper: IR-B RB.